Microbubbles-assisted ultrasonication to promote tumor accumulation of therapeutics and modulation of tumor microenvironment for enhanced cancer treatments

作者全名："Huang, Ju; Zhang, Liang; Zheng, Jun; Lin, Yi; Leng, Xiaojing; Wang, Chunjie; Li, Pan; Feng, Liangzhu"

作者地址："[Huang, Ju; Zhang, Liang; Zheng, Jun; Leng, Xiaojing; Li, Pan] Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging,Dept Ultr, Chongqing 400010, Peoples R China; [Zhang, Liang; Lin, Yi] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing 400042, Peoples R China; [Wang, Chunjie; Feng, Liangzhu] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China"

通信作者："Li, P (通讯作者)，Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging,Dept Ultr, Chongqing 400010, Peoples R China.; Feng, LZ (通讯作者)，Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China."

来源：BIOMATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001017302300001

JCR分区：Q1

影响因子：12.8

年份：2023

卷号：299

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Microbubble-assisted ultrasonication; technology; Enhanced tumor accumulation; Tumor microenvironment modulation; Enhanced cancer treatment

摘要："Abnormal tumor vasculature is reported to severely hinder the therapeutic potency of diverse cancer therapeutics by restricting their intratumoral accumulation and/or causing therapeutic resistance. Herein, a microbubbleassisted ultrasonication technology (MAUT) of systemic administration of octafluoropropane-filled microbubbles together with tumor localized ultrasound (US) exposure is developed to generally promote intratumoral accumulation efficacy of three kinds of anti-tumor drugs with varying sizes through the cavitation effect-induced disruption of tumor blood vessels. MAUT was further shown to enable selective tumor hypoxia attenuation by filling microbubbles with high-purity oxygen and thus reducing the production of immunosuppressive lactic acids by suppressing glycolysis in cancer cells. Resultantly, MAUT markedly enhanced the therapeutic outcome of systemically administered anti-programmed death-1 (anti-PD-1) and chemotherapeutic doxorubicin (DOX) with and without using nanoscale liposomes as delivery vehicles. This work highlights that MAUT is a biocompatible yet versatile strategy to effectively reinforce the therapeutic potency of a broad range of cancer therapeutics, promising for future clinical usage."

基金机构："National Natural Science Foundation of China [82272025, 82202175, 22077093]; Ministry of Science and Technology (MOST) of China [2021YFF0701800, 2022YFF0706500]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0093]; Natural Science Foundation of Jiangsu Province [BK20220110]; Collaborative Innovation Center of Suzhou Nano Science and Technology; Suzhou Key Laboratory of Nanotechnology and Biomedicine; Ministry of Education of China"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82272025, 82202175, 22077093) , the National Research Programs from Ministry of Science and Technology (MOST) of China (2021YFF0701800, 2022YFF0706500) , the Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-MSX0093) , the Natural Science Foundation of Jiangsu Province (BK20220110) , the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Suzhou Key Laboratory of Nanotechnology and Biomedicine, and the 111 Pro- gram from the Ministry of Education of China. We also thank the website of app.Biorender.com for the assistance in creating the illustration figures."