Neutrophil percentage to albumin ratio is associated with stroke-associated pneumonia and poor outcome in patients with spontaneous intracerebral hemorrhage

作者全名："Lv, Xin-Ni; Shen, Yi-Qing; Li, Zuo-Qiao; Deng, Lan; Wang, Zi-Jie; Cheng, Jing; Hu, Xiao; Pu, Ming-Jun; Yang, Wen-Song; Xie, Peng; Li, Qi"

作者地址："[Lv, Xin-Ni; Shen, Yi-Qing; Li, Zuo-Qiao; Deng, Lan; Wang, Zi-Jie; Hu, Xiao; Pu, Ming-Jun; Yang, Wen-Song; Xie, Peng; Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Shen, Yi-Qing; Yang, Wen-Song; Xie, Peng] Chongqing Med Univ, Natl Hlth Commiss NHC Key Lab Diag & Treatment Bra, Affiliated Hosp 1, Chongqing, Peoples R China; [Cheng, Jing] Chongqing Med Univ, Dept Neurol & Neurosurg, Affiliated Hosp 3, Chongqing, Peoples R China; [Li, Qi] Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Li, Q (通讯作者)，Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001017766400001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：intracerebral hemorrhage; pneumonia; inflammation; neutrophil percentage-to-albumin ratio; outcome

摘要："BackgroundThe purpose of this study was to investigate the diagnostic performance of the neutrophil percentage-to-albumin ratio (NPAR) for predicting stroke-associated pneumonia (SAP) and functional outcome in patients with intracerebral hemorrhage (ICH). MethodsWe analyzed our prospective database of consecutive ICH patients who were admitted to the First Affiliated Hospital of Chongqing Medical University from January 2016 to September 2021. We included subjects with a baseline computed tomography available and a complete NPAR count performed within 6h of onset. The patients' demographic and radiological characteristics were analyzed. Good outcome was defined as a modifed Rankin Scale score of 0-3 at 90 days. Poor outcome was defined as a modifed Rankin Scale score of 4-6 at 90 days. Multivariable logistic regression models were used to investigate the association between NPAR, SAP, and functional outcome. Receiver operating characteristic (ROC) curve analysis was conducted to identify the optimal cutoff of NPAR to discriminate between good and poor outcomes in ICH patients. ResultsA total of 918 patients with ICH confirmed by non-contrast computed tomography were included. Of those, 316 (34.4%) had SAP, and 258 (28.1%) had poor outcomes. Multivariate regression analysis showed that higher NPAR on admission was an independent predictor of SAP (adjusted odds ratio: 2.45; 95% confidence interval, 1.56-3.84; P<0.001) and was associated with increased risk of poor outcome (adjusted odd ratio:1.72; 95% confidence interval, 1.03-2.90; P=0.040) in patients with ICH. In ROC analysis, an NPAR of 2 was identified as the optimal cutoff value to discriminate between good and poor functional outcomes. ConclusionHigher NPAR is independently associated with SAP and poor functional outcome in patients with ICH. Our findings suggest that early prediction of SAP is feasible by using a simple biomarker NPAR."

基金机构："National Natural Science Foundation of China [82071337]; National Key Ramp;D Program of China [2018YFC1312200, 2018YFC1312203]; Chongqing High-end Young Investigator Project [2019GDRC005]; Science and Technology Innovation Project of ""Chengdu-Chongqing Economic Circle"" [KJCXZD2020019]; Chongqing Innovation Support Program for Returned Overseas Chinese Scholars [cx2020002]; Chongqing Science Fund for Distinguished Young Scholars [No.cstc2021jcyj-jqX0029]; First Affiliated Hospital of Chongqing Medical University PhD Innovation Program [CYYY-BSYJSCXXM-202314]"

基金资助正文："This study was supported by the National Natural Science Foundation of China (Grant No. 82071337), the National Key R & amp;D Program of China (Grant Nos. 2018YFC1312200 and 2018YFC1312203), the Chongqing High-end Young Investigator Project (Grant No. 2019GDRC005), the Science and Technology Innovation Project of ""Chengdu-Chongqing Economic Circle"" (Grant No. KJCXZD2020019), the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (Grant No. cx2020002), Chongqing Science Fund for Distinguished Young Scholars (Grant No.cstc2021jcyj-jqX0029), and the First Affiliated Hospital of Chongqing Medical University PhD Innovation Program (Grant No. CYYY-BSYJSCXXM-202314)."