Differential analysis of immune reconstitution after allogeneic hematopoietic stem cell transplantation in children with Wiskott-Aldrich syndrome and chronic granulomatous disease

作者全名："Zhou, Ya; Zhang, Luying; Meng, Yan; Lei, Xiaoying; Jia, Lanzhou; Guan, Xianmin; Yu, Jie; Dou, Ying"

作者地址："[Zhou, Ya; Zhang, Luying; Meng, Yan; Lei, Xiaoying; Jia, Lanzhou; Guan, Xianmin; Yu, Jie; Dou, Ying] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Hematol Oncol,Minist Educ,Key Lab Child Dev &, Chongqing, Peoples R China"

通信作者："Dou, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Hematol Oncol,Minist Educ,Key Lab Child Dev &, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001018115700001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：immune reconstruction; lymphocyte reconstruction; allogeneic hematopoietic stem cell transplantation; Wiskott-Aldrich syndrome; chronic granulomatous disease

摘要："ObjectiveTo investigate similarities and differences in immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with Wiskott-Aldrich syndrome (WAS) and chronic granulomatous disease (CGD). MethodWe retrospectively analyzed the lymphocyte subpopulations and the serum level of various immune-related protein or peptide on Days 15, 30, 100, 180 and 360 post-transplantation in 70 children with WAS and 48 children with CGD who underwent allo-HSCT at the Transplantation Center of the Department of Hematology-Oncology, Children's Hospital of Chongqing Medical University from January 2007 to December 2020, and we analyzed the differences in the immune reconstitution process between the two groups. Results ① The WAS group had higher lymphocyte subpopulation counts than the CGD group. ② Among children aged 1-3 years who underwent transplantation, the WAS group had higher lymphocyte subpopulation counts than the CGD group. ③ Further comparisons were performed between children with non-umbilical cord blood transplantation (non-UCBT) and children with umbilical cord blood transplantation (UCBT) in the WAS group. On Day 15 and 30 post-transplantation, the non-UCBT group had higher B-cell counts than the UCBT group. On the remaining time points post-transplantation, the UCBT group had higher lymphocyte subpopulation counts than the non-UCBT group. ④ Comparisons were performed between children with non-UCBT in the WAS group and in the CGD group, the lymphocyte subpopulation counts were higher in the WAS group compared to the CGD group. ⑤ On Day 100 post-transplantation, the CGD group had higher C3 levels than the WAS group. On Day 360 post-transplantation, the CGD group had higher IgA and C4 levels than the WAS group. Conclusion ① The rate of immunity recovery was faster in children within the WAS group compared to those children within the CGD group, which may be attributed to the difference of percentage undergoing UCBT and primary diseases. ② In the WAS group, the non-UCBT group had higher B-cell counts than the UCBT group at Day 15 and 30 post-transplantation, however, the UCBT group had higher B-cell counts than the non-UCBT group at Day 100 and 180 post-transplantation, suggesting that cord blood has strong B-cell reconstitution potentiality after transplantation."

基金机构：Chongqing Medical University Future Medical Youth Innovation Team Development Support Program [W0132]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2021MSXM112]; National Natural Science Foundation of China Youth Science Fund Project [81601753]

基金资助正文："& nbsp;This study was supported by funds from the Chongqing Medical University Future Medical Youth Innovation Team Development Support Program (Grant No. W0132), the Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (Grant No. 2021MSXM112), and the National Natural Science Foundation of China Youth Science Fund Project (Grant No. 81601753)."