Electrochemical nucleic acid sensors: Competent pathways for mobile molecular diagnostics

作者全名："Bai, Huijie; Wang, Yong; Li, Xiaosong; Guo, Jinhong"

作者地址："[Bai, Huijie; Wang, Yong; Guo, Jinhong] Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing 400016, Peoples R China; [Li, Xiaosong] Chongqing Med Univ, Affiliated Hosp 1, Coll Lab Med, Clin Mol Med Testing Ctr, Chongqing 400016, Peoples R China; [Guo, Jinhong] Shanghai Jiao Tong Univ, Sch Sensing Sci & Engn, Shanghai, Peoples R China"

通信作者："Li, XS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Coll Lab Med, Clin Mol Med Testing Ctr, Chongqing 400016, Peoples R China."

来源：BIOSENSORS & BIOELECTRONICS

ESI学科分类：CHEMISTRY

WOS号：WOS:001018556300001

JCR分区：Q1

影响因子：10.7

年份：2023

卷号：237

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Electrochemical biosensor; Nucleic acid; Mobile molecular diagnosis; Microfluidic chip

摘要："Electrochemical nucleic acid biosensor has demonstrated great promise in clinical diagnostic tests, mainly because of its flexibility, high efficiency, low cost, and easy integration for analytical applications. Numerous nucleic acid hybridization-based strategies have been developed for the design and construction of novel electrochemical biosensors for diagnosing genetic-related diseases. This review describes the advances, challenges, and prospects of electrochemical nucleic acid biosensors for mobile molecular diagnosis. Specifically, the basic principles, sensing elements, applications in diagnosis of cancer and infectious diseases, integration with microfluidic technology and commercialization are mainly included in this review, aiming to provide new insights and directions for the future development of electrochemical nucleic acid biosensors."

基金机构：National Natural Sci- ence Foundation of China [62122017]

基金资助正文：The authors thank the financial support from National Natural Sci- ence Foundation of China (62122017) .