Changes of gut mycobiota in the third trimester of pregnant women with preeclampsia

作者全名："Zou, Hua; Zou, Wei; Li, Qian; Chen, Zhen; Shi, Yuanju; Li, Chunli"

作者地址："[Zou, Hua; Zou, Wei; Li, Qian; Li, Chunli] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Clin Lab, Women & Childrens Hosp, Chongqing, Peoples R China; [Chen, Zhen; Shi, Yuanju] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing, Peoples R China; [Li, Chunli] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Clin Lab, Women & Childrens Hosp, Chongqing 400016, Peoples R China"

通信作者："Li, CL (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Clin Lab, Women & Childrens Hosp, Chongqing 400016, Peoples R China."

来源：JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001019814200001

JCR分区：Q2

影响因子：1.8

年份：2023

卷号：36

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：Gut fungal; preeclampsia; glycerophosphocholine; Candida spp; >

摘要："Objective Studies recently acknowledged that the fungal community in the gut plays an important role in many inflammatory diseases of noninfectious origin. but the role of gut fungi in the pathogenesis of preeclampsia (PE) remains unknown. Methods We performed a case-case-control study to compare the gut mycobiota of PE, pregnancy with chronic hypertension (PCH), and the normal group (Normal pregnancy group without any underlying disease) by internal transcribed spacer sequencing. In addition, LC/MS was used to explore the relationship between the fecal metabolites and gut mycobiota. Results Compared with the PCH and the normal group, & alpha; diversity (represented the species abundance in a single sample) of mycobiota were lower in the PE group, but there was no statistically significant difference among these three groups. However, Linear discriminant analysis Effect Size (LEfSe) analysis found 3 differentially abundant fungal taxa in PE group when compared with the normal group. The gut metabolites of PE patients were significantly different from PCH and the normal group. Choline metabolism molecule glycerophosphocholine was the most discriminant metabolite between PE and the normal group. Correlation analysis found that Candida spp.was positively correlated with glycerophosphocholine which increased in PE. Conclusion We found that gut mycobiota changed in the third trimester of pregnant women with preeclampsia."

基金机构：Women and Children's Hospital of Chongqing Medical University [2020YJQN02]

基金资助正文：This study was supported in part by Women and Children's Hospital of Chongqing Medical University (Grant number 2020YJQN02).