No relationship between right-to-left shunt with the severity of white matter hyperintensities

作者全名："Wan, Chengqun; Zou, Qian; Du, Lilan; Wang, Yangyang; Huang, Zhenting; Cai, Zhiyou"

作者地址："[Zou, Qian; Du, Lilan; Cai, Zhiyou] Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China; [Wan, Chengqun; Zou, Qian; Du, Lilan; Cai, Zhiyou] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, Chongqing, Peoples R China; [Wang, Yangyang] Chongqing Univ, Bioengn Coll, Chongqing, Peoples R China; [Huang, Zhenting] Chongqing Med Univ, Chongqing 400042, Peoples R China; [Cai, Zhiyou] Univ Chinese Acad Sci, Chongqing Gen Hosp, 118 Xingguang Ave, Chongqing 401147, Peoples R China; [Cai, Zhiyou] 104 Pipashan Main St, Chongqing 400014, Peoples R China; [Cai, Zhiyou] 312 Zhongshan First Rd, Chongqing 400013, Peoples R China"

通信作者："Cai, ZY (通讯作者)，Univ Chinese Acad Sci, Chongqing Gen Hosp, 118 Xingguang Ave, Chongqing 401147, Peoples R China."

来源：CLINICAL NEUROLOGY AND NEUROSURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001020463900001

JCR分区：Q2

影响因子：1.8

年份：2023

卷号：231

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Magnetic resonance imaging; Patent foramen ovale; White matter; Transcranial Doppler ultrasonography

摘要："Introduction: Studies have shown that right-to-left shunt (RLS) is closely related to the occurrence of white matter hyperintensities (WMHs). Therefore, the detection of RLS is of great significance for the diagnosis and treatment of cerebral small vessel disease, especially for the prevention and treatment of WMHs. In this study, the c-TCD foaming experiment was selected to screen RLS, and evaluate the correlation between RLS and the severity of WMHs.Methods: We enrolled 334 migraineurs from a multicentre study from July 1 2019 and January 31 2020. Par-ticipants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status. RLS was classified into four grades (Grade 0 = Negative; Grade I = 1 & LE;microbubbles (MBs)& LE; 10; Grade II = MBs > 10 and no curtain; Grade III = curtain). Silent brain ischemic infarctions (SBI) and white matter hyperintensities (WMHs) were evaluated on MRI.Results: In the incidence of WMHs, we found a significant difference between patients with RLS and no RLS (p < 0.05). There is no relationship between different grades of RLS and the severity of WMHs (p > 0.05).Conclusion: Overall, the positive rate of RLS is related to the incidence of WMHs. The different grades of RLS have no-relationship to do with the severity of WMHs."

基金机构：Chongqing Natural Science Foundation [cstc2018jcyjAX0602]; Natural Science Foundation of Chongqing [cstc2021jcyj-bsh0154]; Chongqing Health and Family Planning Scientific Research Project [2018ZDXM004]

基金资助正文："This work was supported by the Chongqing Natural Science Foundation (cstc2018jcyjAX0602) , the Natural Science Foundation of Chongqing (cstc2021jcyj-bsh0154) and the Chongqing Health and Family Planning Scientific Research Project (2018ZDXM004) ."