Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression

作者全名："Fu, Yu-Jia; Liu, Xiao; Wang, Xing-Yu; Li, Xiao; Dai, Lin-Qi; Ren, Wen-yu; Zeng, Yong-Ming; Li, Zhen-Lin; Yu, Ren-Qiang"

作者地址："[Fu, Yu-Jia; Liu, Xiao; Wang, Xing-Yu; Ren, Wen-yu; Yu, Ren-Qiang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Li, Xiao; Dai, Lin-Qi] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zeng, Yong-Ming] Chongqing HongRen Yi Hosp, Dept Radiol, Chongqing 408400, Peoples R China; [Li, Zhen-Lin] West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China; [Yu, Ren-Qiang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Yu, RQ (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001021509400010

JCR分区：Q1

影响因子：3.9

年份：2023

卷号：13

期号：6

开始页：386

结束页：396

文献类型：Article

关键词：Voxel-based morphometry; Cerebral blood flow; Arterial spin labeling; Adolescent; Depression; The right percental gyrus

摘要："BACKGROUNDPrior research has demonstrated that the brains of adolescents with depression exhibit distinct structural alterations. However, preliminary studies have documented the pathophysiological changes in certain brain regions, such as the cerebellum, highlighting a need for further research to support the current understanding of this disease.AIMTo study brain changes in depressed adolescents.METHODSThis study enrolled 34 adolescents with depression and 34 age-, sex-, and education-level-matched healthy control (HC) individuals. Structural and functional alterations were identified when comparing the brains of these two participant groups through voxel-based morphometry and cerebral blood flow (CBF) analysis, respectively. Associations between identified brain alterations and the severity of depressive symptoms were explored through Pearson correlation analyses.RESULTSThe cerebellum, superior frontal gyrus, cingulate gyrus, pallidum, middle frontal gyrus, angular gyrus, thalamus, precentral gyrus, inferior temporal gyrus, superior temporal gyrus, inferior frontal gyrus, and supplementary motor areas of adolescents with depression showed an increase in brain volume compared to HC individuals. These patients with depression further presented with a pronounced drop in CBF in the left pallidum (group = 98, and peak t = - 4.4324), together with increased CBF in the right percental gyrus (PerCG) (group = 90, and peak t = 4.5382). In addition, 17-item Hamilton Depression Rating Scale scores were significantly correlated with the increased volume in the opercular portion of the left inferior frontal gyrus (r = - 0.5231, P < 0.01).CONCLUSIONThe right PerCG showed structural and CBF changes, indicating that research on this part of the brain could offer insight into the pathophysiological causes of impaired cognition."

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