Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease

作者全名："Zhu, Yuxia; Li, Sichen; Da, Xiaohui; Lai, Hongyu; Tan, Changhong; Liu, Xi; Deng, Fen; Chen, Lifen"

作者地址："[Zhu, Yuxia; Li, Sichen; Da, Xiaohui; Lai, Hongyu; Tan, Changhong; Liu, Xi; Deng, Fen; Chen, Lifen] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Liu, X; Deng, F (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001022071500001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Parkinson's disease; White matter asymmetry; Diffusion tensor imaging; Onset side; Predicting mode

摘要："BackgroundParkinson's disease (PD) is characterized by a lateralized onset, but its cause and mechanism are still unclear.MethodsObtaining diffusion tensor imaging (DTI) data from the Parkinson's Progression Markers Initiative (PPMI). Tract-based spatial statistics analysis and region-of-interest-based analysis were performed to evaluate the white matter (WM) asymmetry using original DTI parameters, Z Score normalized parameters, or the asymmetry index (AI). Hierarchical cluster analysis and least absolute shrinkage and selection operator regression were performed to construct predictive models for predicting the PD onset side. DTI data from The Second Affiliated Hospital of Chongqing Medical University were obtained for external validation of the prediction model.Results118 PD patients and 69 healthy controls (HC) from PPMI were included. Right-onset PD patients presented more asymmetric areas than left-onset PD patients. The inferior cerebellar peduncle (ICP), superior cerebellar peduncle (SCP), external capsule (EC), cingulate gyrus (CG), superior fronto-occipital fasciculus (SFO), uncinate fasciculus (UNC), and tapetum (TAP) showed significant asymmetry in left-onset and right-onset PD patients. An onset-side-specific pattern of WM alterations exists in PD patients, and a prediction model was constructed. The predicting models based on AI and & UDelta;Z Score presented favorable efficacy in predicting PD onset side by external validation in 26 PD patients and 16 HCs from our hospital.ConclusionsRight-onset PD patients may have more severe WM damage than left-onset PD patients. WM asymmetry in ICP, SCP, EC, CG, SFO, UNC, and TAP may predict PD onset side. Imbalances in the WM network may underlie the mechanism of lateralized onset in PD."

基金机构：National Natural Science Foundation of China [82001367]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0180]; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University; Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN202200417]

基金资助正文："This study was supported by National Natural Science Foundation of China (grant number: 82001367, receiver: Xi Liu), Natural Science Foundation of Chongqing (grant number: cstc2021jcyj-msxmX0180, receiver: Xi Liu), Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University (receiver: Xi Liu), and Scientific and Technological Research Program of Chongqing Municipal Education Commission (grant number: KJQN202200417, receiver: Changhong Tan)"