"Matrix stiffness, endothelial dysfunction and atherosclerosis"

作者全名："Xu, Zichen; Chen, Yi; Wang, Yi; Han, Wenbo; Xu, Wenfeng; Liao, Xiaoling; Zhang, Tao; Wang, Guixue"

作者地址："[Xu, Zichen; Han, Wenbo; Wang, Guixue] Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China; [Chen, Yi; Xu, Wenfeng; Liao, Xiaoling; Zhang, Tao] Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Engn Lab Nano Micro Biomed Detect, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R China; [Wang, Yi] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Wang, Guixue] Chongqing Univ, Bioengn Coll, 174 Shazheng St, Chongqing 400030, Peoples R China"

通信作者："Wang, GX (通讯作者)，Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China.; Zhang, T (通讯作者)，Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Engn Lab Nano Micro Biomed Detect, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R China.; Wang, GX (通讯作者)，Chongqing Univ, Bioengn Coll, 174 Shazheng St, Chongqing 400030, Peoples R China."

来源：MOLECULAR BIOLOGY REPORTS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001022083000003

JCR分区：Q3

影响因子：2.6

年份：2023

卷号：50

期号：8

开始页：7027

结束页：7041

文献类型：Review

关键词：Matrix stiffness; Endothelial cells; Atherosclerosis; Macrophage; EC phagocytosis

摘要："Atherosclerosis (AS) is the leading cause of the human cardiovascular diseases (CVDs). Endothelial dysfunction promotes the monocytes infiltration and inflammation that participate fundamentally in atherogenesis. Endothelial cells (EC) have been recognized as mechanosensitive cells and have different responses to distinct mechanical stimuli. Emerging evidence shows matrix stiffness-mediated EC dysfunction plays a vital role in vascular disease, but the underlying mechanisms are not yet completely understood. This article aims to summarize the effect of matrix stiffness on the pro-atherosclerotic characteristics of EC including morphology, rigidity, biological behavior and function as well as the related mechanical signal. The review also discusses and compares the contribution of matrix stiffness-mediated phagocytosis of macrophages and EC to AS progression. These advances in our understanding of the relationship between matrix stiffness and EC dysfunction open the avenues to improve the prevention and treatment of now-ubiquitous atherosclerotic diseases."

基金机构："National Natural Science Key Foundation of China [12032007]; Chongqing Talents [cstc2022ycjh-bgzxm0166]; Natural Science Foundation of Chongqing in China [cstc2020jcyj-bsh0024, cstc2019jcyj-zdxmX0028]"

基金资助正文："AcknowledgementsThis study was supported by grants from the National Natural Science Key Foundation of China (Project no. 12032007), Chongqing Talents (cstc2022ycjh-bgzxm0166), the Natural Science Foundation of Chongqing in China (cstc2020jcyj-bsh0024, cstc2019jcyj-zdxmX0028)."