"Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis"

作者全名："Zhao, Huiying; Li, Xintong; Zheng, Yongqi; Zhu, Xiaofeng; Qi, Xunzhong; Huang, Xinyan; Bai, Shunjie; Wu, Chengji; Sun, Guangtao"

作者地址："[Zhao, Huiying] Jiamusi Univ, Dept Neurol, Jiamusi, Heilongjiang, Peoples R China; [Li, Xintong] Shenzhen Univ, Affiliated Hosp 3, Dept Neurol, Shenzhen, Guangdong, Peoples R China; [Zheng, Yongqi] Yichun Forestry Adm Cent Hosp, Dept Internal Med, Yichun, Heilongjiang, Peoples R China; [Zhu, Xiaofeng] Mudanjiang Med Coll, Dept Neurol, Mudanjiang, Heilongjiang, Peoples R China; [Qi, Xunzhong; Wu, Chengji; Sun, Guangtao] Jiamusi Univ, Affiliated Hosp 1, Dept Neurol, Jiamusi, Heilongjiang, Peoples R China; [Huang, Xinyan] Jiamusi Univ, Affiliated Hosp 2, Dept Neurol, Jiamusi, Heilongjiang, Peoples R China; [Bai, Shunjie] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China"

通信作者："Zhu, XF (通讯作者)，Mudanjiang Med Coll, Dept Neurol, Mudanjiang, Heilongjiang, Peoples R China.; Qi, XZ (通讯作者)，Jiamusi Univ, Affiliated Hosp 1, Dept Neurol, Jiamusi, Heilongjiang, Peoples R China."

来源：PEERJ

ESI学科分类：Multidisciplinary

WOS号：WOS:001023212100004

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Astrocytes; Alcohol; Fasudil; ROCK pathway; Metabolomics; Lipid metabolism

摘要："Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for death, illness, and disability. Rho kinase inhibitors have neuroprotective effects. This study used metabonomics analysis to assess untreated astrocytes, astrocytes exposed to 75 mmol/L of alcohol, and astrocytes exposed to 75 mmol/L of alcohol and treated with 15 & mu;g/mL fasudil for 24 h. One of the clearest differences between the alcohol-exposed and fasudil-treated alcohol-exposed groups was the abundance of lipids and lipid-like molecules, although glycerophospholipid metabolism was comparable in both groups. Our findings show that fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, providing a new approach for preventing and treating alcohol dependence."

基金机构："Doctoral Initiation Project of Jiamusi University [JMSUBZ2019-06]; Heilongjiang Province Educational Commission of China; National Key Ramp;D Program of China [81901398]; National Natural Science Foundation of China [cstc2019jcyj-msxmX0025]; Natural Science Foundation of Chongqing, China [2019-KYYWF-1357]; Talent training project for basic scientific research of Heilongjiang Province Educational Commission of China; [2018YFC1314404]"

基金资助正文："Xunzhong Qi received funding from the Doctoral Initiation Project of Jiamusi University (grant numbers: JMSUBZ2019-06) and the Talent training project for basic scientific research of Heilongjiang Province Educational Commission of China (grant numbers: 2019-KYYWF-1357). Xiaofeng Zhu received funding from The National Key R & amp;D Program of China (grant numbers: 2018YFC1314404), the Shunjie Bai received funding from the National Key R & amp;D Program of China (grant numbers: 2018YFC1314404); National Natural Science Foundation of China (grant numbers:81901398), and the Natural Science Foundation of Chongqing, China (grant numbers: cstc2019jcyj-msxmX0025). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."