L. pneumophila Infection Diagnosed by tNGS in a Lady with Lymphadenopathy

作者全名："Li, Shiying; Tong, Jin; Li, Hu; Mao, Chenxue; Shen, Wei; Lei, Yu; Hu, Peng"

作者地址："[Li, Shiying; Li, Hu; Shen, Wei; Lei, Yu; Hu, Peng] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China; [Tong, Jin] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China; [Mao, Chenxue] ChongQing KingMed Ctr Clin Lab Co Ltd, Dept Lab Diag, Chongqing 400050, Peoples R China; [Hu, Peng] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Hu, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001023921000001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：16

期号：　

开始页：4435

结束页：4442

文献类型：Article

关键词：case report; Legionella pneumophila; targeted next-generation sequencing; tNGS; precision treatment; levofloxacin

摘要："We report a case of a 34-year-old lady with multiple joint pain. Autoimmune diseases were considered first with a positive result of anti-Ro antibody and her right knee joint cavity effusion. Later, bilateral interstitial changes in her lungs and mediastinal lymphadenopathy were found after chest CT scanning. Empirical quinolone therapy was given although pathological examinations of blood, sputum and bronchoalveolar lavage fluid (BALF) did not find anything. Finally, Legionella pneumophila was identified by target next-generation sequencing (tNGS) detection. This case highlighted the timely use of tNGS, a new tool with fast speed, high accuracy and effective cost, could help to identify atypical infection and start an early therapy."

基金机构：Chongqing Talents Project [cstc2021ycjh-bgzxm0150]; General Program of Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0901]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [kryc-yq-2204]

基金资助正文："Funding This work was supported by the Chongqing Talents Project (cstc2021ycjh-bgzxm0150) , the General Program of Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0901) , and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (kryc-yq-2204) ."