Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases

作者全名："Li, Jingwen; Li, Xinyue; Song, Sijie; Sun, Zhengwen; Li, Yuanzhu; Yang, Long; Xie, Zhenhong; Cai, Yikui; Zhao, Yinping"

作者地址："[Li, Jingwen; Li, Xinyue; Song, Sijie; Sun, Zhengwen; Li, Yuanzhu; Yang, Long; Xie, Zhenhong; Cai, Yikui; Zhao, Yinping] Chongqing Med Univ, Management Ctr, Lab Tissue & Cell Biol, Lab Teaching, 1 Med Coll Rd, Chongqing 400016, Peoples R China"

通信作者："Zhao, YP (通讯作者)，Chongqing Med Univ, Management Ctr, Lab Tissue & Cell Biol, Lab Teaching, 1 Med Coll Rd, Chongqing 400016, Peoples R China."

来源：REDOX BIOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001024558100001

JCR分区：Q1

影响因子：10.7

年份：2023

卷号：64

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Vascular smooth muscle cells; Cell phenotype; Mitochondria; Cytoskeleton; Atherosclerosis

摘要："Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health, which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC phenotypic transformation is marked by the alteration of phenotypic marker expression and cellular behaviour. Intriguingly, the mitochondrial metabolism and dynamics altered during VSMC phenotypic transformation. Firstly, this review combs VSMC mitochondrial metabolism in three aspects: mitochondrial ROS generation, mutated mitochondrial DNA (mtDNA) and calcium metabolism respectively. Secondly, we summarized the role of mitochondrial dynamics in regulating VSMC phenotypes. We further emphasized the association between mitochondria and cytoskelton via presenting cytoskeletal support during mitochondrial dynamics process, and discussed its impact on their respective dynamics. Finally, considering that both mitochondria and cytoskeleton are mechano-sensitive organelles, we demonstrated their direct and indirect interaction under extracellular mechanical stimuli through several mechano-sensitive signaling pathways. We additionally discussed related researches in other cell types in order to inspire deeper thinking and reasonable speculation of potential regulatory mechanism in VSMC phenotypic transformation."

基金机构：National Natural Science Foundation of China [82100493]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0189]; Project of Science and Technology of Chongqing Yuzhong District [20200111]; National College Students Innovation and Entrepreneurship Training Program [LTMCMTS202102]; Laboratory of Tissue and Cell Biology of Chongqing Medical University; Project of Tutorial System of Medical Undergraduate in Lab Teaching amp; Management Center in Chongqing Medical University; [202210631002]; [LTMCMTS202213]; [LTMCMTS202214]

基金资助正文："This study was supported by grants from the National Natural Science Foundation of China (82100493), the Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0189), the Project of Science and Technology of Chongqing Yuzhong District (20200111), and the Project of Tutorial System of Medical Undergraduate in Lab Teaching & amp; Management Center in Chongqing Medical University (LTMCMTS202213, LTMCMTS202214, LTMCMTS202102), National College Students Innovation and Entrepreneurship Training Program (202210631002). . The supported funding mentioned above are highly appreciated. The support from Laboratory of Tissue and Cell Biology of Chongqing Medical University is also gratefully acknowledged."