Using computed tomography angiography and computational fluid dynamics to study aortic coarctation in different arch morphologies

作者全名："Qin, Jinjie; Ouyang, Da; Yan, Taocui; Wang, Haoru; Guo, Kui; Jin, Xin; Pan, Zhengxia; He, Ling"

作者地址："[Qin, Jinjie; Wang, Haoru; He, Ling] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Minist Educ,Key Lab Child Dev & Disord, Chongqing, Peoples R China; [Ouyang, Da] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Dept Cardiol,Minist Educ,Key Lab Child Dev & Disor, Chongqing, Peoples R China; [Yan, Taocui] Chongqing Med Univ, Med Data Sci Acad, Coll Med Informat, Chongqing, Peoples R China; [Guo, Kui; Jin, Xin; Pan, Zhengxia] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Dept Cardiothorac Surg,Minist Educ,Key Lab Child D, Chongqing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Minist Educ,Key Lab Child Dev & Disord, Chongqing, Peoples R China.; Pan, ZX (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Dept Cardiothorac Surg,Minist Educ,Key Lab Child D, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001025406300001

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：aortic coarctation (CoA); gothic arch; computational fluid dynamics (CFD); AAO-DAO angle; computed tomography angiography (CTA)

摘要："Objective: To study the differences in computed tomography angiography (CTA) imaging of gothic arches, crenel arches, and romanesque arches in children with Aortic Coarctation (CoA), and to apply computational fluid dynamics (CFD) to study hemodynamic changes in CoA children with gothic arch aorta. Methods: The case data and CTA data of children diagnosed with CoA (95 cases) in our hospital were retrospectively collected, and the morphology of the aortic arch in the children was defined as gothic arch (n = 27), crenel arch (n = 25) and romanesque arch (n = 43). The three groups were compared with D1/AOA, D2/ AOA, D3/AOA, D4/AOA, D5/AOA, and AAO-DAO angle, TAO-DAO angle, and aortic arch height to width ratio (A/T). Computational fluid dynamics was applied to assess hemodynamic changes in children with gothic arches. Results: There were no significant differences between D1/AOA and D2/AOA among gothic arch, crenel arch, and romanesque arch (P > 0.05). The differences in D3/AOA, D4/AOA, and D5/AOA among the three groups were statistically significant (P< 0.05), D4/AOA, D5/AOA of the gothic arch group were smaller than the crenel arch group, and the D3/AOA and D5/AOA of the gothic arch group were smaller than the romanesque arch group (P < 0.05). The difference in AAO-DAO angle among the three groups was statistically significant (P < 0.05), and the AAO-DAO angle of gothic arch was smaller than that of romanesque arch and crenel arch group (P< 0.05). There was no significant difference in the TAO-DAO angle between the three groups (P > 0.05). The difference in A/T values among the three groups was statistically significant (P < 0.05), and the A/T values: gothic arch > romanesque arch > crenel arch (P < 0.05). The CFD calculation of children with gothic arch showed that the pressure drop between the distal stenosis and the descending aorta was 58 mmHg, and the flow rate at the isthmus and descending aorta was high and turbulent. Conclusion: Gothic aortic arch is common in CoA, it may put adverse effects on the development of the aortic isthmus and descending aorta, and its A/T value and AAO-DAO angle are high. CFD could assess hemodynamic changes in CoA."

基金机构："Basic Research and Frontier Exploration Project (Yuzhong District, Chongqing, China) [20200155]; Project of Chongqing general project [2020jcyj-msxm0282, CSTC2021jscx-gksb-N0018]"

基金资助正文："& nbsp;The project was funded by the Basic Research and Frontier Exploration Project (Yuzhong District, Chongqing, China) (Grant No. 20200155) and the Project of Chongqing general project (No. cstc 2020jcyj-msxm0282, No. CSTC2021jscx-gksb-N0018)."