High diastereo- and enantioselective Michael addition of 3-acetoxy-2-oxindoles with nitroalkenes catalyzed by nickel/PyBisulidine

作者全名："Wu, Ruoran; Chen, Peng; Chai, Yu; Zhou, Junyu; Ou, Jianhua; Min, Yan; Wang, Haoting; Liang, Guojuan; Zhang, Dong; Zhou, Jing; Zhou, Hui"

作者地址："[Wu, Ruoran; Chen, Peng; Chai, Yu; Zhou, Junyu; Ou, Jianhua; Min, Yan; Wang, Haoting; Liang, Guojuan; Zhang, Dong; Zhou, Jing; Zhou, Hui] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Zhou, H (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：ORGANIC & BIOMOLECULAR CHEMISTRY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001031595900001

JCR分区：Q1

影响因子：2.9

年份：2023

卷号：21

期号：30

开始页：6225

结束页：6229

文献类型：Article

关键词：　

摘要："A Ni/PyBisulidine catalyzed asymmetric Michael addition of 3-acyloxy-2-oxindoles to nitroalkenes has been developed. Various quaternary substituted 3-acyloxy-2-oxindoles were obtained with excellent yields and diastereo- and enantioselectivities in a low-toxic green solvent, ethyl acetate, with a low catalyst loading (1 mol%). The reaction process is air and moisture tolerant. The substrate scope was also extended to & alpha;,& beta;-disubstituted nitroalkenes and 3-hydroxy-2-oxindoles, and good results were obtained."

基金机构：National Natural Science Foundation of China [21672031]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0034]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201900437]

基金资助正文："The work was supported by the National Natural Science Foundation of China (21672031), the Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0034), and the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN201900437)."