Preparation of polydopamine-based concave nanoparticles and mild photothermal-anti-inflammatory combination therapy for breast cancer guided by magnetic resonance imaging

作者全名："Ni, Chen; Lu, Jiahui; Chen, Zhian; Yang, Jinfeng; Huang, Jie; Guo, Xinyi; Shi, Meilin"

作者地址："[Ni, Chen; Lu, Jiahui; Chen, Zhian; Yang, Jinfeng; Huang, Jie; Guo, Xinyi; Shi, Meilin] Xuzhou Med Univ, Sch Med Imaging, Xuzhou 221004, Jiangsu, Peoples R China; [Ni, Chen] Chongqing Med Univ, State Key Lab Ultrasound Engn Med Cofounded Chongq, Chongqing 400016, Peoples R China; [Ni, Chen] Chongqing Med Univ, Coll Biomed Engn, Chongqing Key Lab Biomed Engn, Minist Sci & Technol, Chongqing 400016, Peoples R China; [Lu, Jiahui] Hangzhou Med Coll, Sch Med Imaging, Hangzhou 310059, Zhejiang, Peoples R China; [Shi, Meilin] Xuzhou Med Univ, Inst Med Imaging & Digital Med, Xuzhou 221004, Peoples R China"

通信作者："Shi, ML (通讯作者)，Xuzhou Med Univ, Sch Med Imaging, Xuzhou 221004, Jiangsu, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001031988200001

JCR分区：Q1

影响因子：7.6

年份：2023

卷号：229

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Breast cancer; Nanoparticles; Magnetic resonance imaging; Mild photothermal; Anti-inflammatory therapy

摘要："Photothermal therapy (PTT) has been widely investigated as a regimen for superficial tumors. However, conventional PTT strategies usually require photothermal temperatures above 50 & DEG;C to achieve significant therapeutic efficacy, which in effect would lead to injury to adjacent normal tissues and meanwhile, the heat generated by the photothermal effect would induce inflammation owing to the damage to cytoplas-mic components. In order to reduce the toxicity of photothermal therapy and increase the efficiency of photothermal tumor destruction, novel strategies are prerequisite for targeted regimen and surveillance of photothermal therapy in real time. In this paper, we reported a concave mesoporous polydopamine-targeting nanotherapeutic agent. We employed B-MPDA as the carrier and encapsulated CQ and ASP to yield B-MPDA/CQ/ASP which was loaded with autophagy inhibitors and anti-inflammatory agents and coated uniformly with MnO2 Nanosheet. With HA functionalizing MnO2 Nanosheet, B-MPDA/CQ/ ASP@MnO2-HA was constituted. The yielded nanoparticles were identified to be advantageous for good biocompatibility, potent targeting and low toxicity. In anti-tumor regimens, the nanoparticles can be applied to hyaluronic acid targeting, mesoporous polydopamine thermotherapy, and autophagy inhibitor sensitization thermotherapy, and simultaneously eliminate the inflammatory effects induced by pho-tothermal therapy. Furthermore, in combination with the anti-inflammatory effect of targeting tumor, this agent can effectively induce apoptosis of cancer cells and significantly improve the efficiency of mild photothermal killing of cancer cells, which provides insight into the development of nanoparticles and application to mild photothermal therapy in the clinical scenario. & COPY; 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构：National Natural Science Foundation of China [81602533]; China Postdoctoral Science Foundation [2021 M692710]; Postdoctoral Research Funding Program of Jiangsu Province [2021K190B]; Xuzhou innovation project [KC21175]; Jiangsu Qinglan Project; Postgraduate Research amp; Practice Innovation Program of Jiangsu Province [KYCX21_2644]

基金资助正文："This work was supported by the National Natural Science Foundation of China (81602533), China Postdoctoral Science Foundation (2021 M692710), Postdoctoral Research Funding Program of Jiangsu Province (2021K190B), Xuzhou innovation project (KC21175), Jiangsu Qinglan Project, Postgraduate Research & amp; Practice Innovation Program of Jiangsu Province (KYCX21_2644)."