Monitoring neonatal brain hemorrhage progression by photoacoustic tomography

作者全名："Shan, Tianqi; Yang, Hao; Jiang, Shixie; Jiang, Huabei"

作者地址："[Shan, Tianqi] Univ Florida, Dept Biomed Engn, Gainesville, FL USA; [Shan, Tianqi] Chongqing Med Univ, Coll Biomed Engn, Chongqing, Peoples R China; [Yang, Hao; Jiang, Huabei] Univ S Florida, Dept Mech Engn, Tampa, FL 33620 USA; [Jiang, Shixie] Univ S Florida, Dept Psychiat & Behav Neurosci, Tampa, FL USA"

通信作者："Jiang, HB (通讯作者)，Univ S Florida, Dept Mech Engn, Tampa, FL 33620 USA."

来源：BIOMEDICAL OPTICS EXPRESS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001032012100009

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Neonatal brain hemorrhage (NBH) is the most common neurological disorder in neonates and its clinical interventions are very limited. Understanding the pathology of NBH by non-invasive in-vivo characterization of standardized animal models is essential for developing potential treatments. Currently, there is no suitable tool to provide non-invasive, non-ionizing dynamic imaging of neonatal mouse models with high resolution, high contrast, and deep imaging depth. In this study, we implemented a fast 3D photoacoustic tomography (PAT) system suitable for imaging neonatal mouse brains with good image quality and demonstrated its feasibility in non-invasive monitoring of the dynamic process of NBH in the whole neonatal mouse brain. The results present a high resolution and sensitivity for NBH detection. Both morphological and hemodynamic changes of the hematoma were accurately obtained. Our results demonstrated the potential of PAT as a powerful tool for the preclinical study of neonatal brain hemorrhage. (c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement"

基金机构：National Institutes of Health [5R01AA028200]

基金资助正文：National Institutes of Health (5R01AA028200).