Sodium houttuyfonate exerts its neuroprotection effect by inhibiting the M1 microglia polarization in a TLR4/NF-kappa B signal pathway

作者全名："Tang, Wei; Liu, Lu; Yan, Yi; Xia, Yongzhi"

作者地址："[Tang, Wei; Yan, Yi; Xia, Yongzhi] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China; [Liu, Lu] Army Med Ctr PLA, Dept Oral & Maxillofacial Surg, Chongqing 400016, Peoples R China"

通信作者："Xia, YZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China."

来源：BRAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001032516300001

JCR分区：Q3

影响因子：2.7

年份：2023

卷号：1809

期号：　

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结束页：　

文献类型：Article

关键词："Spinal cord injury; Sodium houttuyfonate; Neuroinflammation; TLR4, NF-kappa B"

摘要："Neuroinflammation plays an important role in secondary injury after spinal cord injury (SCI) and may aggravate neurological dysfunction. Several studies have indicated that sodium houttuyfonate (SH) can significantly inhibit macrophage-mediated inflammation; however, its effects on SCI still needs to be elucidated. We found that SH improved Basso, Beattie, and Bresnahan scores and performance in the inclined plane test of SCI model rats. The injured spinal cord exhibited less neuronal loss, cell apoptosis, and M1 microglial polarization after SH treat-ment. In vitro, SH reduced TLR4/NF-kappa B expression in cultured primary microglia and decreased M1 microglial polarization and cell apoptosis in a lipopolysaccharide (LPS)-pretreated microglia and neuron coculture system. These results indicated that SH may exert a neuroprotective effect by inhibiting M1 microglial polarization after SCI via the TLR4/NF-kappa B signalling pathway."

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