Anti-LINGO-1 antibody protects neurons and synapses in the medial prefrontal cortex of APP/PS1 transgenic mice

作者全名："Zhou, Yu-Ning; Jiang, Lin; Zhang, Yi; Zhou, Chun-Ni; Yang, Hao; He, Qi; Wang, Yi-Ying; Xiao, Qian; Huang, Du-Juan; Luo, Yan-Min; Tang, Yong; Chao, Feng-Lei"

作者地址："[Zhou, Yu-Ning; Zhou, Chun-Ni; Yang, Hao; He, Qi; Wang, Yi-Ying; Huang, Du-Juan; Tang, Yong; Chao, Feng-Lei] Chongqing Med Univ, Fac Basic Med Sci, Dept Histol & Embryol, Chongqing 400016, Peoples R China; [Zhou, Yu-Ning; Zhou, Chun-Ni; Yang, Hao; He, Qi; Wang, Yi-Ying; Huang, Du-Juan; Tang, Yong; Chao, Feng-Lei] Chongqing Med Univ, Fac Basic Med Sci, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China; [Jiang, Lin] Chongqing Med Univ, Expt Teaching Management Ctr, Chongqing 400016, Peoples R China; [Zhang, Yi] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China; [Xiao, Qian] Chongqing Med Univ, Fac Basic Med Sci, Dept Radioact Med, Chongqing 400016, Peoples R China; [Luo, Yan-Min] Chongqing Med Univ, Fac Basic Med Sci, Dept Physiol, Chongqing 400016, Peoples R China"

通信作者："Tang, Y; Chao, FL (通讯作者)，Chongqing Med Univ, Fac Basic Med Sci, Dept Histol & Embryol, Chongqing 400016, Peoples R China."

来源：NEUROSCIENCE RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001032758100001

JCR分区：Q3

影响因子：2.4

年份：2023

卷号：193

期号：　

开始页：28

结束页：40

文献类型：Article

关键词：LINGO-1; Neuron; Synapse; Medial prefrontal cortex; Alzheimer's disease

摘要："The medial prefrontal cortex (mPFC), one of the most vulnerable brain regions in Alzheimer's disease (AD), plays a critical role in cognition. Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptorinteracting protein-1 (LINGO-1) negatively affects nerve growth in the central nervous system; however, its role in the pathological damage to the mPFC remains to be studied in AD. In this study, an anti-LINGO-1 antibody was administered to 10-month-old APP/PS1 mice, and behavioral tests, stereological methods, immunohistochemistry and immunofluorescence were used to answer this question. Our results revealed that LINGO-1 was highly expressed in the neurons of the mPFC of AD mice, and the anti-LINGO-1 antibody improved prefrontal cortex-related function and reduced the protein level of LINGO-1, atrophy of the volume, A & beta; deposition and massive losses of synapses and neurons in the mPFC of AD mice. Antagonizing LINGO-1 could effectively alleviate the pathological damage in the mPFC of AD mice, which might be an important structural basis for improving prefrontal cortex-related function. Abnormal expression of LINGO-1 in the mPFC may be one of the key targets of AD, and the effect initiated by the anti-LINGO-1 antibody may provide an important basis in the search for drugs for the prevention and treatment of AD."

基金机构："National Natural Science Foundation of China (NSFC) [82171522]; NSFC [cstc2020jcyj- msxmX0125]; Natural Science Foundation of Chongqing, P. R. China [cstc2021jcyj- msxmX0105, 82002227]"

基金资助正文："This study was supported by the National Natural Science Foundation of China (NSFC, 82171522; NSFC, 82002227) and the Natural Science Foundation of Chongqing, P. R. China (cstc2020jcyj- msxmX0125; cstc2021jcyj- msxmX0105) ."