Novel DNA nanoflower biosensing technologies towards next-generation molecular diagnostics

作者全名："Sheng, Jing; Pi, Yan; Zhao, Shuang; Wang, Binpan; Chen, Ming; Chang, Kai"

作者地址："[Sheng, Jing; Zhao, Shuang; Wang, Binpan; Chen, Ming; Chang, Kai] Army Med Univ, Southwest Hosp, Dept Clin Lab Med, 30 Gaotanyan, Chongqing 400038, Peoples R China; [Pi, Yan] Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Chongqing 400042, Peoples R China; [Chen, Ming] Army Med Univ, Coll Pharm & Lab Med, 30 Gaotanyan, Chongqing 400038, Peoples R China; [Chen, Ming] Army Med Univ, State Key Lab Trauma Burn & Combined Injury, 30 Gaotanyan, Chongqing 400038, Peoples R China"

通信作者："Chen, M; Chang, K (通讯作者)，Army Med Univ, Southwest Hosp, Dept Clin Lab Med, 30 Gaotanyan, Chongqing 400038, Peoples R China.; Chen, M (通讯作者)，Army Med Univ, Coll Pharm & Lab Med, 30 Gaotanyan, Chongqing 400038, Peoples R China.; Chen, M (通讯作者)，Army Med Univ, State Key Lab Trauma Burn & Combined Injury, 30 Gaotanyan, Chongqing 400038, Peoples R China."

来源：TRENDS IN BIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001033028500001

JCR分区：Q1

影响因子：14.3

年份：2023

卷号：41

期号：5

开始页：653

结束页：668

文献类型：Review

关键词：　

摘要："DNA nanoflowers (DNFs) are topological flower-like nanostructures based on ultralong-strand DNA and inorganic metal-ion frameworks. Because of their programmability, biocompatibility, and controllable assembly size for specific responses to molecular recognition stimuli, DNFs are powerful biosensing tools for detecting biomolecules. Here, we review the current state of DNF-based bio-sensing strategies for in vivo and in vitro detection, with a view of how the field has evolved towards molecular diagnostics. We also provide a detailed classifica-tion of DNF-based biosensing strategies and propose their future utility. Particularly as transduction elements, DNFs can accelerate biosensing engineering by signal amplification. Finally, we discuss the key challenges and further prospects DNF-based biosensing technologies in developing applications of a broader scope."

基金机构："National Natural Science Foundation of China [82122042, 82030066, 81972027]; Chongqing Health Commission [2019QNXM039]"

基金资助正文："Acknowledgments This study was supported by the National Natural Science Foundation of China (Grant No. 82122042, 82030066, 81972027) , and Chongqing Health Commission (No. 2019QNXM039) ."