Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

作者全名："Zhong, Ling; Zhang, Wanlin; Krummenacher, Claude; Chen, Yixin; Zheng, Qingbing; Zhao, Qinjian; Zeng, Mu-Sheng; Xia, Ningshao; Zeng, Yi-Xin; Xu, Miao; Zhang, Xiao"

作者地址："[Zhong, Ling; Zhang, Wanlin; Zeng, Mu-Sheng; Zeng, Yi-Xin; Xu, Miao; Zhang, Xiao] Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Dept Expt Res, Canc Ctr,State Key Lab Oncol South China,Collabora, Guangzhou, Guangdong, Peoples R China; [Krummenacher, Claude] Rowan Univ, Dept Biol & Biomed Sci, Glassboro, NJ USA; [Chen, Yixin; Zheng, Qingbing; Xia, Ningshao] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen, Fujian, Peoples R China; [Zhao, Qinjian; Zhang, Xiao] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China"

通信作者："Xu, M; Zhang, X (通讯作者)，Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Dept Expt Res, Canc Ctr,State Key Lab Oncol South China,Collabora, Guangzhou, Guangdong, Peoples R China.; Zhang, X (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China."

来源：TRENDS IN MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001033465200001

JCR分区：Q1

影响因子：14

年份：2023

卷号：31

期号：8

开始页：788

结束页：804

文献类型：Review

关键词：　

摘要："Herpesviruses are among the most successful viruses found in human populations. They establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry process of herpesviruses into specific target cells requires a well-orchestrated teamwork involving multiple envelope glycoproteins. The conserved glycoprotein B (gB) is the membrane fusogen, of which conformational changes are induced by an entry complex (EC) consisting of at least gH and gL. Despite the high prevalence and heavy disease burdens associated with human herpesviruses (HHVs), vaccines against these pathogens are still lacking, except for varicella zoster virus (VZV). Recent advances in understanding the coordinated mechanisms of action of the key EC glycoproteins and fusogen will help to improve approaches for effective vaccine development and neutralizing antibody (nAb) screening."

基金机构："National Natural Science Foundation of China [81702001, 82122050]; National Key Research and Development Program of China [2022YFC2305400]; Guangdong Basic and Applied Basic Research Foundation [2020B1515020002]"

基金资助正文：Acknowledgments This work was supported by the grant from the National Natural Science Foundation of China (81702001 to X.Z. and 82122050 to M.X.) ; National Key Research and Development Program of China Grant 2022YFC2305400 (to M.X.) ; and Guangdong Basic and Applied Basic Research Foundation Grant 2020B1515020002 (to M.X.) .