"Structure, function, and pathology of Neurexin-3"

作者全名："Zhang, Rui; Jiang, HanXiao; Liu, YuanJie; He, GuiQiong"

作者地址："[Zhang, Rui; Liu, YuanJie; He, GuiQiong] Chongqing Med Univ, Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China; [Jiang, HanXiao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing 400010, Peoples R China; [Liu, YuanJie; He, GuiQiong] Chongqing Med Univ, Dept Anat, Chongqing 400016, Peoples R China; [Liu, YuanJie; He, GuiQiong] 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Liu, YJ; He, GQ (通讯作者)，1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001034578300001

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：10

期号：5

开始页：1908

结束页：1919

文献类型：Review

关键词：Excitatory synapses; Inhibitory synapses; Neural cell adhesion molecules; Neurexin-3; Neurodegenerative diseases; Neuropsychiatric diseases

摘要："Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic membrane. Neurexin-3 has important roles in synapse development and synapse functions. Neurexin-3 mediates excitatory presynaptic differentiation by interacting with leucine-rich-repeat transmembrane neuronal proteins. Meanwhile, neurexin-3 modulates the expression of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors and g-aminobutyric acid A receptors by interacting with neuroligins at excitatory and inhibitory synapses. Numerous studies have documented the potential contribution of neurexin-3 to neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease, addiction behaviors, and other diseases, which raises hopes that understanding the mechanisms of neurexin-3 may hold the key to developing new strategies for related illnesses. This review comprehensively covers the literature to provide current knowledge of the structure, function, and clinical role of neurexin-3.& COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构：Science and Technology Innovation Project of Chongqing Education Commission (China) [KJCXZD2020021]

基金资助正文：Funding This work was supported by the Science and Technology Innovation Project of Chongqing Education Commission (China) (No. KJCXZD2020021) .