Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?

作者全名："Deng, Longfei; Liang, Ping; Cui, Hongjuan"

作者地址："[Deng, Longfei; Cui, Hongjuan] Southwest Univ, Med Res Inst, Canc Ctr, Chongqing 400716, Peoples R China; [Liang, Ping] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neurosurg,Minist Educ,Key Lab Child Dev & Dis, Chongqing 400014, Peoples R China; [Liang, Ping] Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China; [Cui, Hongjuan] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400716, Peoples R China"

通信作者："Cui, HJ (通讯作者)，Southwest Univ, Med Res Inst, Canc Ctr, Chongqing 400716, Peoples R China.; Liang, P (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neurosurg,Minist Educ,Key Lab Child Dev & Dis, Chongqing 400014, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001034697100001

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：10

期号：5

开始页：1937

结束页：1955

文献类型：Review

关键词：Cancer therapy; Clinical translation; Gene delivery; Lentiviral vector; Pseudotype

摘要："Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene ther-apy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudo -typing, have altered tropism and display cell-type specificity in transduction, leading to selec-tive tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies. The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed.& COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构：National Natural Science Foundation of China [81872071]; Fundamental Research Funds for the Central Universities (China) [SWU120054]; Natural Science Foundation of Chongqing (China) [cstc2019jcyj-zdxmX0033]; Funda-mental Research Funds for the Central Universities (China) [XYDS201912]

基金资助正文："Funding This work was supported by the National Natural Science Foundation of China (No. 81872071) , the Fundamental Research Funds for the Central Universities (China) (No. SWU120054) , the Natural Science Foundation of Chongqing (China) (No. cstc2019jcyj-zdxmX0033) , and the Funda-mental Research Funds for the Central Universities (China) (No. XYDS201912) ."