Altered distribution of fatty acid exerting lipid metabolism and transport at the maternal-fetal interface in fetal growth restriction

作者全名："Yang, Zhongmei; Luo, Xiaofang; Huang, Biao; Jia, Xiaoyan; Luan, Xiaojin; Shan, Nan; An, Zhongling; Cao, Jinfeng; Qi, Hongbo"

作者地址："[Yang, Zhongmei; Huang, Biao; Jia, Xiaoyan; Luan, Xiaojin; Shan, Nan; An, Zhongling; Cao, Jinfeng; Qi, Hongbo] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China; [Yang, Zhongmei] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Obstet & Gynecol, Chengdu 610072, Peoples R China; [Luo, Xiaofang] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing 400016, Peoples R China; [Yang, Zhongmei; Luo, Xiaofang; Huang, Biao; Jia, Xiaoyan; Luan, Xiaojin; Shan, Nan; An, Zhongling; Cao, Jinfeng; Qi, Hongbo] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Yang, Zhongmei; Luo, Xiaofang; Huang, Biao; Jia, Xiaoyan; Luan, Xiaojin; Shan, Nan; An, Zhongling; Cao, Jinfeng] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chinese Minist Educ, Chongqing 400016, Peoples R China; [Yang, Zhongmei] Sichuan Translat Med Res Hosp, Chinese Acad Sci, Chengdu 610072, Peoples R China"

通信作者："Yang, ZM; Qi, HB (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China."

来源：PLACENTA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001034703100001

JCR分区：Q1

影响因子：3

年份：2023

卷号：139

期号：　

开始页：159

结束页：171

文献类型：Article

关键词：Fetal growth restriction; Fatty acids; Linoleic acid metabolism; Metabolomics; Placenta

摘要："Introduction: Fetal growth restriction (FGR) is a common complication of pregnancy. Lipid metabolism and distribution may contribute to the progression of FGR. However, the metabolism-related mechanisms of FGR remain unclear. The aim of this study was to identify metabolic profiles associated with FGR, as well as probable genes and signaling pathways. Methods: Metabolomic profiles at the maternal-fetal interface (including the placenta, maternal and fetal serum) from pregnant women with (n = 35) and without (n = 35) FGR were analyzed by gas chromatography-mass spectrometry (GC-MS). Combined with differentially expressed genes (DEGs) from the GSE35574 dataset, analysis was performed for differential metabolites, and identified by the Metabo Analyst dataset. Finally, the pathology and screened DEGs were further identified. Results: The results showed that fatty acids (FAs) accumulated in the placenta and decreased in fetal blood in FGR cases compared to controls. The linoleic acid metabolism was the focus of placental differential metabolites and genes enrichment analysis. In this pathway, phosphatidylcholine can interact with PLA2G2A and PLA2G4C, and 12(13)-EpOME can interact with CYP2J2. PLA2G2A and CYP2J2 were elevated, and PLA2G4C was decreased in the FGR placenta. Discussion: In conclusion, accumulation of FAs in the placental ischemic environments, may involve linoleic acid metabolism, which may be regulated by PLA2G2A, CYP2J2, and PLA2G4C. This study may contribute to un-derstanding the underlying metabolic and molecular mechanisms of FGR."

基金机构："National Key Research and Development Program of China [2022YFC2704702]; Na-tional Natural Science Foundation of China [81771613, 81771614, 81901506, 82001581, 82001582, 82001573]; China Postdoctoral Science Foundation [2022M710560]"

基金资助正文："Funding This work was supported by grants from the National Key Research and Development Program of China (No. 2022YFC2704702) , the Na-tional Natural Science Foundation of China (No. 81771613, 81771614, 81901506, 82001581, 82001582 and 82001573) , China Postdoctoral Science Foundation (2022M710560) ."