Recognition and analysis of biomarkers in tumor microenvironments based on promising molecular imprinting strategies with high selectivity
作者全名："He, Jia-Yuan; Li, Qin; Xu, Hui-Xian; Zheng, Qin-Yue; Zhang, Qi-Hui; Zhou, Lian-Di; Wang, Chong-Zhi; Yuan, Chun-Su"
作者地址："[He, Jia-Yuan; Li, Qin; Xu, Hui-Xian; Zhang, Qi-Hui] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China; [Zhou, Lian-Di] Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China; [Zheng, Qin-Yue] Chongqing Inst Food & Drug Control, Chongqing 401121, Peoples R China; [Wang, Chong-Zhi; Yuan, Chun-Su] Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA; [Wang, Chong-Zhi; Yuan, Chun-Su] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA"
通信作者："Zhang, QH (通讯作者)，Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China.; Zhou, LD (通讯作者)，Chongqing Med Univ, Basic Med Coll, Chongqing 400016, Peoples R China."
来源：TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ESI学科分类：CHEMISTRY
WOS号：WOS:001035716200001
JCR分区：Q1
影响因子：11.8
年份：2023
卷号：162
期号：
开始页：
结束页：
文献类型：Review
关键词：Molecularly imprinted polymers; Cancer diagnosis; Tumor microenvironment; Biomarker
摘要："Rapidly and selectively detecting and analyzing biomarkers are important objectives for diagnosis, therapy, and prognosis of different malignant tumors. Due to the complexity and variability of tumor microenvironment components, it is essential to develop highly specific biomarker-targeted analytical methods. Molecularly imprinted polymers (MIPs) are synthetic antibody materials with high selectivity and strong affinity for targets. The unique properties and functions of MIPs make them an emerging platform for designing precise specific recognition systems. For precise analysis, MIPs-based specific recognition systemsdthrough fluorescence imaging, biomarker sensing, and targeted recognitions of the disease microenvironmentdcan achieve accurate designed recognition strategies. Herein, we discuss the selective recognition and sensing systems based on molecular imprinting technologies, highlight their characteristics, and present strategies to achieve selective recognition and sensing. Given the rapid development of tools of analytical chemistry, we expect the design and development of MIPs-based specific recognition and sensing systems to be further flourished in the future. & COPY; 2023 Elsevier B.V. All rights reserved."
基金机构："National Natural Science Foundation of China [81973451]; Fundamental and Frontier Research Fund of Chongqing [cstc2018jcyjAX0661, cstc2019jsyj-yzysbAX0 020]; Graduate Research and Innovation Project of Chongqing [2022 (CYB22041)]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K201800103]; Fundamental Research Funds for the Central Universities [2019CDYGYB027, 2022CDJXY-0 03]; Graduate Research and Innovation Foundation of Chongqing [CYS18033]; Venture amp; Innovation Support Program for Chongqing Overseas Returnees; Tang Foundations"
基金资助正文："This work was financially supported by National Natural Science Foundation of China (81973451) , Fundamental and Frontier Research Fund of Chongqing (cstc2018jcyjAX0661, cstc2019jsyj-yzysbAX0 020) , Graduate Research and Innovation Project of Chongqing, 2022 (CYB22041) , the Science and Technology Research Program of Chongqing Municipal Education Commission (KJZD-K201800103) , Fundamental Research Funds for the Central Universities (2019CDYGYB027, 2022CDJXY-0 03) , Graduate Research and Innovation Foundation of Chongqing (CYS18033) , Venture & Innovation Support Program for Chongqing Overseas Returnees, and Tang Foundations."
