The Diagnostic Potential of Circulating Autoantibodies to Amyloid-beta in Alzheimer's Disease
作者全名："Xu, Guang-Yu; Liu, Yu-Hao; Zeng, Xiao-Qin; Chen, Dong-Wan; Zeng, Gui-Hua; Fan, Dong-Yu; Liu, Yu-Hui; Wang, Yan-Jiang"
作者地址："[Xu, Guang-Yu; Liu, Yu-Hao; Zeng, Xiao-Qin; Chen, Dong-Wan; Zeng, Gui-Hua; Fan, Dong-Yu; Liu, Yu-Hui; Wang, Yan-Jiang] Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing, Peoples R China; [Xu, Guang-Yu; Liu, Yu-Hao; Zeng, Xiao-Qin; Chen, Dong-Wan; Zeng, Gui-Hua; Fan, Dong-Yu; Liu, Yu-Hui; Wang, Yan-Jiang] Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing, Peoples R China; [Fan, Dong-Yu] Third Mil Med Univ, Shigatse Branch, Xinqiao Hosp, Shigatse, Peoples R China; [Liu, Yu-Hui; Wang, Yan-Jiang] Key Lab Aging & Brain Dis, Chongqing, Peoples R China; [Wang, Yan-Jiang] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China"
通信作者："Fan, DY; Liu, YH; Wang, YJ (通讯作者)，Third Mil Med Univ, Chongqing, Peoples R China."
来源：JOURNAL OF ALZHEIMERS DISEASE
ESI学科分类：NEUROSCIENCE & BEHAVIOR
WOS号：WOS:001035839200013
JCR分区：Q2
影响因子：3.4
年份：2023
卷号：94
期号：2
开始页：537
结束页：546
文献类型：Article
关键词：Alzheimer's disease; amyloid-beta; autoantibodies; biomarkers; diagnosis
摘要："Background: The profile of naturally occurring antibodies to amyloid-beta (NAbs-A beta) is altered in patients with Alzheimer's disease (AD). However, the diagnostic potential of NAbs-A beta for AD is not clear yet. Objective: This study aims to investigate the diagnostic capacities of NAbs-A beta for AD. Methods: A total of 40 AD patients and 40 cognitively normal (CN) controls were enrolled in this study. Levels of NAbs-A beta were detected by ELISA. The correlations of NAbs-A beta levels with cognitive function and AD-associated biomarkers were examined by Spearman correlation analysis. Diagnostic abilities of NAbs-A beta were evaluated by the receiver operating characteristic (ROC) curve analyses. The integrative diagnostic models were established by logistic regression models. Results: We found that NAbs-A beta 7-18 had the highest diagnostic capability (AUC= 0.72) among all single NAbs-A beta. The combined model (NAbs-A beta 7-18, NAbs-A beta 19-30, and NAbs-A beta 25-36) had a noticeable improvement (AUC= 0.84) in the diagnostic capacity compared with each single NAbs-A beta. Conclusion: NAbs-A beta s are promising in the diagnosis of AD. Further investigations are needed to confirm the translational potential of this diagnostic strategy."
基金机构："National Natural Science Foundation of China [81930028, 82201585]; Innovation enhancing project of the Army Medical University [2021XQN23]"
基金资助正文："This study was supported by National Natural Science Foundation of China (81930028 to WYJ, 82201585 to FDY) and Innovation enhancing project of the Army Medical University (2021XQN23 to LYH)."
