Comparison of pregnancy outcomes in infertile patients with different types of adenomyosis treated with high-intensity focused ultrasound

作者全名："Wei, Jiajia; Wang, Li; Tao, Hua; Wang, Xindan; Zheng, Fengque; He, Ping; Zhou, Linggang; Fan, Li; Chen, Jing; Zhong, Haijing; Huang, Wenjie; Zeng, Dingyuan; Li, Jingjing"

作者地址："[Wei, Jiajia; Wang, Li; Tao, Hua; Wang, Xindan; Fan, Li; Chen, Jing; Zhong, Haijing; Huang, Wenjie; Zeng, Dingyuan; Li, Jingjing] Liuzhou Matern & Child Healthcare Hosp, Dept Gynecol, Liuzhou, Guangxi, Peoples R China; [Wang, Li; Tao, Hua; Zeng, Dingyuan] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Zheng, Fengque; He, Ping; Zhou, Linggang] Guangxi Med Univ, Affiliated Hosp 4, Dept Obstet & Gynecol, Liuzhou, Guangxi, Peoples R China"

通信作者："Zeng, DY; Li, JJ (通讯作者)，Liuzhou Matern & Child Healthcare Hosp, Dept Gynecol, Liuzhou, Guangxi, Peoples R China.; Zeng, DY (通讯作者)，Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001036273800001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Adenomyosis; infertility; high-intensity focused ultrasound; pregnancy outcomes; >

摘要："Objective This study assessed the improvement of symptoms and pregnancy outcomes in infertile patients with various types of adenomyosis who were treated with high-intensity focused ultrasound (HIFU). Materials and methods Between October 2017 and January 2022, 129 infertile patients with adenomyosis who wished to conceive were treated with HIFU. Based on the relationship between the adenomyotic lesion, the endometrium, and the subserosa of the uterus on magnetic resonance imaging, the adenomyotic lesions were divided into internal, external, intramural, and full-thickness types. Menstruation pain score, menstruation blood volume score, anti-Mullerian hormone (AMH) levels, reproductive results, pregnancy and delivery complications, and other clinical variables were compared among these four groups. Results Patients with external adenomyosis had the greatest menstrual distress, whereas patients with internal adenomyosis had the greatest menstrual blood volume. Dysmenorrhea and heavy menstruation were significantly improved after HIFU treatment in all groups. AMH levels were not significantly different before and six months after HIFU. Of the 129 patients, 50 (38.7%) became pregnant after HIFU, and patients with internal adenomyosis had the highest pregnancy rate. Patients with adenomyotic lesions located in the posterior wall of the uterus had a higher pregnancy rate than those with lesions located in the fundus of the uterus. Conclusions The classification of adenomyosis is closely related to distinctions in clinical symptoms and pregnancy outcomes. Infertile patients with different types of adenomyosis could be effectively treated with HIFU. HIFU can be considered as an option for infertile patients with adenomyosis who want to maintain their fertility."

基金机构：Guangxi Science and Technology Plan Project from Guangxi Clinical Research Center for Obstetrics and Gynecology [AD22035223]; Key Research and Development Program of Guangxi [Guike AB18126056]; State Key Laboratory of Ultrasound Medical Engineering Open subject [2020KFA3012]

基金资助正文："This work was supported by the Guangxi Science and Technology Plan Project under Grant from the Guangxi Clinical Research Center for Obstetrics and Gynecology, GuiKe AD22035223; Key Research and Development Program of Guangxi under Grant No. Guike AB18126056; and State Key Laboratory of Ultrasound Medical Engineering Open subject under Grant No.2020KFA3012."