Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria

作者全名："Luo, Huirong; Wang, Xueqian; Zhang, Yinlin; Li, Junyao; Hu, Renqin; Zhang, Zheng; Liao, Qian; Zhou, Xiaoxin; Deng, Wei; Yang, Jian; Luo, Qinghua"

作者地址："[Luo, Huirong; Wang, Xueqian; Zhang, Yinlin; Li, Junyao; Hu, Renqin; Zhang, Zheng; Luo, Qinghua] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China; [Liao, Qian] Chongqing KingMed Inst Clin Lab Co LTD, Dept Lab Diagnost, Chongqing, Peoples R China; [Zhou, Xiaoxin] Chongqing Med Univ, Affiliated Hosp 3, Dept Clin Nutr, Chongqing, Peoples R China; [Deng, Wei] Zhejiang Univ, Affiliated Mental Hlth Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China; [Deng, Wei] Zhejiang Univ, Hangzhou Peoples Hosp 7, Sch Med, Hangzhou, Zhejiang, Peoples R China; [Yang, Jian] Chongqing Med Univ, Affiliated Hosp 3, Res Ctr Metab & Cardiovasc Dis, Chongqing 400016, Peoples R China"

通信作者："Luo, QH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China.; Yang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Res Ctr Metab & Cardiovasc Dis, Chongqing 400016, Peoples R China."

来源：ANNALS OF MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001036753300001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：55

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：Bipolar disorder; circadian rhythms; actigraphy; neurocognitive functioning; research domain criteria (RDoC); >

摘要："Introduction: Bipolar disorder (BD) is a prevalent and disabling mental disorder characterized by disrupted circadian rhythms and impaired neurocognitive features, both of which fall under the major domains of Research Domain Criteria (RDoC). However, there is limited evidence regarding the interaction between circadian rhythms and long-term neurocognitive functioning. Therefore, this longitudinal cohort study protocol aims to explore whether circadian rhythm can predict changes in neurocognitive functioning over time in patients with BD. Methods: This study adopts a longitudinal cohort design, aiming to recruit 100 BD patients in either depressive or remitted states. Participants will undergo evaluations from clinical, circadian rhythm, and neurocognitive perspectives at baseline, 6-month, and 12-month follow-ups, involving questionnaires, actigraphy, and computed neurocognitive tests. We will examine both cross-sectional and longitudinal associations between participants' circadian rhythm patterns and neurocognitive functioning. Statistical analyses will employ Spearman correlation and mixed regression models. Discussion: We anticipate that circadian rhythms may serve as predictors of neurocognitive functioning changes. The findings of this study could offer supplementary insights into BD pathophysiology, potential treatment targets, and prediction."

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