Decreased lymphocyte count before conditioning is associated with BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

作者全名："Xie, Xiang-ting; Zhang, Yan-fang; Zhang, Ying; Zeng, Han-qing; Deng, Jian-chuan; Zhou, Kang; Chen, Lin; Luo, Yun; Lou, Shi-feng"

作者地址："[Xie, Xiang-ting; Zhang, Yan-fang; Zhang, Ying; Zeng, Han-qing; Deng, Jian-chuan; Zhou, Kang; Chen, Lin; Luo, Yun; Lou, Shi-feng] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, 288 Tian Wen Rd, Chongqing 400010, Peoples R China"

通信作者："Luo, Y (通讯作者)，Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, 288 Tian Wen Rd, Chongqing 400010, Peoples R China."

来源：INTERNATIONAL IMMUNOPHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001037661700001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：121

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：BK virus; Hematopoietic stem cell transplantation; Risk factors; Prognosis

摘要："Background: BK virus-associated hemorrhagic cystitis (BKV-HC) is a serious complication after allogeneic he-matopoietic stem cell transplantation (allo-HSCT). It can cause morbidity and may increase treatment-related mortality. Previous studies showed that the occurrence of BKV-HC was related to various factors. However, there are still many controversial factors. It is not clear whether BKV-HC will affect the long-term prognosis of patients. Objective: We aimed to identify risk factors for BKV-HC after allo-HSCT and evaluate the effect of BKV-HC on overall survival (OS) and progression-free survival (PFS) of patients. Study Design: We retrospectively analyzed the clinical data of 93 patients who underwent allo-HSCT. Univariate and multivariate analysis were used to identify risk factors for BKV-HC. The Kaplan-Meier method was used to estimate OS and PFS. A difference was considered statistically significant if P < 0.05. Results: A total of 24 patients developed BKV-HC. The median occurrence time of BKV-HC was 30 (range:8-89) days after transplantation, and the median duration was 25.5 (range:6-50) days. Multivariate logistic regression analysis indicated that peripheral blood lymphocyte count <1 x 109/L before conditioning (OR = 4.705, P = 0.007) and haploidentical transplantation (OR = 13.161, P = 0.018) were independent risk factors for BKV-HC. The 3-year OS rate was 85.9% (95%CI:62.1%-95.2%) in the BKV-HC group and 73.1% (95%CI: 58.2%-88.0%) in the non-BKV-HC group. There was no significant difference between the two groups (P = 0.516). The 3-year PFS rate was 76.3% (95%CI: 57.9%-94.7%) in the BKV-HC group and 58.1% (95%CI: 39.5%-76.7%) in the non-BKV-HC group. There was no significant difference in the two groups (P = 0.459). The severity of BKV-HC was not related to the OS and PFS of the patients (P value was 0.816 and 0.501, respectively). Conclusion: Haploidentical transplantation and decreased peripheral blood lymphocyte count before conditioning increased the risk of BKV-HC after allo-HSCT. The occurrence of BKV-HC after allo-HSCT and the severity of which did not affect OS and PFS of the patients."

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