An ultrasound-responsive smart nanoplatform leads to mitochondrial apoptosis of tumor cells from multiple levels

作者全名："Chen, Huan; Li, Qin; Kang, Hongmei; Yuan, Pei; Zhang, Liangke"

作者地址："[Chen, Huan; Li, Qin; Kang, Hongmei; Yuan, Pei; Zhang, Liangke] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Zhang, LK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:001038892600001

JCR分区：Q1

影响因子：13.3

年份：2023

卷号：470

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Sonodynamic therapy; CO therapy; Chemodynamic therapy; Ca 2+overload

摘要："Mitochondria, the energy suppliers of cells, are crucial for cell survival and proliferation. Tumor therapy based on mitochondrial apoptosis holds good promise. Currently utilized strategies, such as the production of CO and ROS and Ca2+ overload, are not highly selective and have limited effectiveness. In this study, a smart nanoplatform (V-Mn@Ca) controlled by ultrasound (US) and with high therapeutic efficacy was designed, which can specifically target the tumor site and activate mitochondrial apoptosis at multiple levels. Specifically, VS4, featuring a narrow band gap, are utilized to generate a Fenton-like effect. Loading Mn(CO)5Br enables a USinduced release of CO and depletion of GSH, which would further enhance ROS-mediated mitochondrial apoptosis. Finally, an encapsulated CaCO3 shell layer disrupts Ca2+ homeostasis in tumor cells. Overall, our study shows that the V-Mn@Ca platform triggers CO, ROS, and Ca2+ production in a controlled manner. Thus, providing sonodynamic therapy and CO therapy on a timed-targeted basis for enhanced mitochondrial apoptosis and subsequent tumor cell death, which inhibits tumor growth."

基金机构：Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0795]

基金资助正文：This work was supported by the Natural Science Foundation Project of CQ CSTC (cstc2018jcyjAX0795) .