Feasibility and efficacy of ultrasound-guided high-intensity focused ultrasound of breast fibroadenoma

作者全名："Liang, Mengdi; Zhang, Zhizheng; Zhang, Cai; Chen, Rui; Xiao, Yao; Li, Zi; Li, Tao; Liu, Yuelin; Ling, Lijun; Xie, Hui; Chen, Lin; Liu, Xiaoan; Wang, Shui; Xia, Tiansong"

作者地址："[Liang, Mengdi; Zhang, Zhizheng; Chen, Rui; Liu, Yuelin; Ling, Lijun; Xie, Hui; Chen, Lin; Liu, Xiaoan; Wang, Shui; Xia, Tiansong] Nanjing Med Univ, Dept Breast Surg, Affiliated Hosp 1, Nanjing, Peoples R China; [Zhang, Cai; Xiao, Yao; Li, Zi; Xia, Tiansong] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Zhang, Cai] Chongqing Haifu Hosp, Chongqing, Peoples R China; [Zhang, Cai] Natl Engn Res Ctr Ultrasound Med, Chongqing, Peoples R China; [Li, Tao] Nanjing Med Univ, Dept Pathol, Affiliated Hosp 1, Nanjing, Peoples R China; [Wang, Shui; Xia, Tiansong] Nanjing Med Univ, Dept Breast Surg, Affiliated Hosp 1, Nanjing 210029, Peoples R China; [Xia, Tiansong] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China"

通信作者："Wang, S; Xia, TS (通讯作者)，Nanjing Med Univ, Dept Breast Surg, Affiliated Hosp 1, Nanjing 210029, Peoples R China.; Xia, TS (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001041694500001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound (HIFU); breast fibroadenoma; ablative technique; minimally invasive surgery; benign breast tumor; >

摘要："Objective This nonrandomized prospective clinical trial aimed to assess the efficacy, safety and follow-up outcomes of ultrasound-guided high-intensity focused ultrasound (USgHIFU) surgery in patients with breast fibroadenoma. Methods With the approval of the institutional ethics committee and written informed consent, a total of 113 patients diagnosed with breast fibroadenoma by core-needle biopsy in our hospital were recruited. USgHIFU surgery was performed under local anesthesia. Contrast-enhanced ultrasound (CEUS) or contrast-enhanced MRI (CEMRI) was performed to evaluate the nonperfused volume (NPV). The patients were followed up with physical examination and ultrasound imaging. Results The clinical outcome of 85 patients with 147 fibroadenomas with a follow-up time of more than 3 months was analyzed in this study. Fifty-two patients had one lesion, twenty-one patients had two lesions and twelve patients had more than two lesions. During USgHIFU, the median localization time for all fibroadenomas was 3 (interquartile range: 1, 5) min, and the median treatment time was 9 (interquartile range: 5, 15) min. Under local anesthesia, all the patients tolerated the treatment well. No serious epidermal burns were observed in any of the patients. Based on CEUS or CEMRI imaging evaluation, the median NPV ratio was 100% (interquartile range: 79.2%, 116.8%). The VRR were 26.77 & PLUSMN; 50.05%, 50.22 & PLUSMN; 42.01% and 72.74 & PLUSMN; 35.39% at 3-6 months, 6-12 months and >12 months, respectively, which showed significant statistical difference (p < .001). Conclusion Ultrasound-guided HIFU surgery is an effective and safe noninvasive alternative technique for the treatment of breast fibroadenoma."

基金机构："Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering [2021KFKT002, 2021KFKT014, 2022KFKT009]"

基金资助正文："This study was supported by the Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering [Grant No. 2021KFKT002, Grant No. 2021KFKT014 and Grant No. 2022KFKT009]."