CXC chemokines influence immune surveillance in immunological disorders: Polycystic ovary syndrome and endometriosis

作者全名："Ullah, Amin; Wang, Mei-Jiao; Wang, Ying-Xiong; Shen, Bairong"

作者地址："[Ullah, Amin; Shen, Bairong] Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Xinchuan Rd, Chengdu, Sichuan, Peoples R China; [Wang, Ying-Xiong] Chongqing Med Univ, Sch Publ Hlth, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Wang, Mei-Jiao; Wang, Ying-Xiong] Chongqing Med Univ, Sch Basic Med, Dept Genet, Chongqing, Peoples R China; [Wang, Mei-Jiao] Chongqing Med Univ, Sch Basic Med, Dept Physiol, Chongqing, Peoples R China"

通信作者："Ullah, A; Shen, BR (通讯作者)，Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Xinchuan Rd, Chengdu, Sichuan, Peoples R China."

来源：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001042061700001

JCR分区：Q1

影响因子：4.2

年份：2023

卷号：1869

期号：5

开始页：　

结束页：　

文献类型：Review

关键词：CXC chemokines; Polycystic ovary syndrome (PCOS); Endometriosis; Inflammation; Therapeutic strategies

摘要："Reproductive health is a worldwide challenge, but it is of particular significance to women during their reproductive age. Several female reproductive problems, including polycystic ovary syndrome (PCOS) and endometriosis, affect about 10 % of women and have a negative impact on their health, fertility, and quality of life. Small, chemotactic, and secreted cytokines are CXC chemokines. Both PCOS and endometriosis demonstrate dysregulation of CXC chemokines, which are critical to the development and progression of both diseases. Recent research has shown that both in humans and animals, CXC chemokines tend to cause inflammation. It has also been found that CXC chemokines are necessary for promoting angiogenesis and inflammatory responses. CXC chemokine overexpression is frequently associated with poor survival and prognosis. CXC chemokine levels in PCOS and endometriosis patients impact their circumstances significantly. Hence, CXC chemokines have significant potential as diagnostic and prognostic biomarkers and therapeutic targets. The molecular mechanisms through which CXC chemokines promote inflammation and the development of PCOS and endometriosis are currently unknown. This article will discuss the functions of CXC chemokines in the promotion, development, and therapy of PCOS and endometriosis, as well as future research directions. The current state and future prospects of CXC chemokine-based therapeutic strategies in the management of PCOS and endometriosis are also highlighted."

基金机构："National Natural Science Foundation of China [32070671, 32270690]; West China Hospital Sichuan University - Sichuan and Guangxi Provinces [HX-2019-nCoV-057, 2020YFQ0019]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (32070671, 32270690) , the Covid-19 research projects of West China Hospital Sichuan University (Grant no. HX-2019-nCoV-057) as well as the regional innovation cooperation between Sichuan and Guangxi Provinces (2020YFQ0019) ."