Case report: sudden death following the administration of CAR-NK cells for lung cancer immunotherapy

作者全名："Zhao, Congcong; Zhang, Li; Zheng, Zhe; Li, Yongguo; Xiong, Hongli; Zhu, Ying; Wang, Qi; Zhao, Minzhu; Li, Jianbo"

作者地址："[Zhao, Congcong; Zhang, Li; Zheng, Zhe; Li, Yongguo; Xiong, Hongli; Zhu, Ying; Wang, Qi; Zhao, Minzhu; Li, Jianbo] Chongqing Med Univ, Dept Forens Med, Chongqing 400010, Peoples R China; [Zhao, Congcong; Li, Yongguo; Xiong, Hongli; Zhu, Ying; Wang, Qi; Zhao, Minzhu; Li, Jianbo] Chongqing Engn Res Ctr Criminal Invest Technol, Chongqing 400010, Peoples R China; [Zhao, Congcong; Li, Yongguo; Xiong, Hongli; Zhu, Ying; Wang, Qi; Zhao, Minzhu; Li, Jianbo] Chongqing Key Lab Forens Med, Chongqing 400010, Peoples R China; [Zhang, Li] Chongqing Coll Tradit Chinese Med, Chongqing 400010, Peoples R China; [Zheng, Zhe] Henan Univ Sci & Technol, Dept Forens Med, Luoyang 471023, Henan, Peoples R China"

通信作者："Zhao, MZ; Li, JB (通讯作者)，Chongqing Med Univ, Dept Forens Med, Chongqing 400010, Peoples R China.; Zhao, MZ; Li, JB (通讯作者)，Chongqing Engn Res Ctr Criminal Invest Technol, Chongqing 400010, Peoples R China.; Zhao, MZ; Li, JB (通讯作者)，Chongqing Key Lab Forens Med, Chongqing 400010, Peoples R China."

来源：FORENSIC SCIENCE MEDICINE AND PATHOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001042787400001

JCR分区：Q2

影响因子：1.5

年份：2023

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文献类型：Article; Early Access

关键词：CAR-NK cells; Lung cancer; Cytokine storm; Immunotherapy; Inflammatory factors

摘要："Lung cancer is a high degree of malignancy. Although surgery, radiotherapy, and chemotherapy have made significant progress and become general methods of clinical treatment, the overall survival rate is still low. In recent years, targeted therapy and immunotherapy have a rapid development in the clinical treatment of tumors. Among them, natural killer (NK) cells have the advantages of rapid killing of diseased cells and low risk of graft-versus-host reaction. It is considered a great vector for chimeric antigen receptors (CARs), making them have good application prospects in tumor immunotherapy. However, its clinical application in lung cancer needs further research. Herein, we reported a case of a lung cancer patient undergoing CAR-NK cell immunotherapy after resection, which caused a cytokine storm and sudden death after the fourth treatment. This case report provides a reference for the forensic examination of cadavers that died after immunotherapy and challenges the clinical application of cell immunotherapy."

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