Retrospective study of risk factors for pericardial effusion after haematopoietic stem cell transplantation in children

作者全名："Tong, Ke; Meng, Yan; Zhang, Luying; Lei, Xiaoying; Guan, Xianmin; Xiao, Li; Yu, Jie; Dou, Ying"

作者地址："[Tong, Ke; Meng, Yan; Zhang, Luying; Lei, Xiaoying; Guan, Xianmin; Yu, Jie; Dou, Ying] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Dept Hematol & Oncol,Chongqing Key Lab Pediat,Chil, Chongqing, Peoples R China; [Xiao, Li] Chongqing Med Univ, Big Data Ctr Childrens Med Care, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Dou, Y (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Dept Hematol & Oncol,Chongqing Key Lab Pediat,Chil, Chongqing, Peoples R China."

来源：HEMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001043142100001

JCR分区：Q3

影响因子：2

年份：2023

卷号：28

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Haematopoietic stem cell transplantation; pericardial effusion; risk factors; children; >

摘要："Objectives The clinical characteristics, risk factors and survival prognosis of pericardial effusion (PE) after haematopoietic stem cell transplantation (HSCT) in children were investigated. Methods Clinical data of children who underwent HSCT at the Children's Hospital Affiliated with Chongqing Medical University from January 2016 to December 2022 were analysed retrospectively. Cox proportional hazards regression and the Kaplan-Meier method were used to analyse the risk factors for post-HSCT PE and its impact on outcomes, respectively. Results We enrolled 452 patients with HSCT: 307 males and 145 females, with a median age of 3.4 (1.8 to 6.5) years at transplantation. Forty-five patients (10%) had PE within a median time of 25 (10.5 to 44) days, 42 (93%) within 100 days. Three patients with large PE were treated with pericardiocentesis and drainage, while the others were treated conservatively. Of the 45 patients with PE, 24 survived, and their PE disappeared after treatment. Graft-versus-host disease (GVHD) grade, abnormal pre-HSCT electrocardiogram, hepatic veno-occlusive disease (HVOD), pulmonary infection and Epstein-Barr virus (EBV) infection were risk factors for PE. The overall survival (OS) rates at 1, 3, and 5 years were 86.0%, 84.2%, and 82.3%, respectively. PE had a significant negative effect on OS after HSCT (P < 0.0001). Particularly, one patient with large PE died of pericardial tamponade. Conclusions Post-HSCT PE usually occurred within 100 days. GVHD grade, abnormal pre-HSCT electrocardiogram, HVOD, pulmonary infection and EBV infection were closely related to PE. PE had a significant negative effect on OS rate."

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