Phototherapy: a new risk factor for necrotizing enterocolitis in very low birth weight preterm infants? a retrospective case-control study

作者全名："Li, Jie; Zhong, Xiao-Yun; Zhou, Li-Gang; Wu, Yan; Wang, Li; Song, Si-Jie"

作者地址："[Li, Jie; Zhong, Xiao-Yun; Zhou, Li-Gang; Wu, Yan; Wang, Li; Song, Si-Jie] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pediat, Chongqing, Peoples R China"

通信作者："Song, SJ (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pediat, Chongqing, Peoples R China."

来源：JOURNAL OF PERINATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001043647400002

JCR分区：Q1

影响因子：2.4

年份：2023

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期号：　

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文献类型：Article; Early Access

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摘要："ObjectiveTo investigate the association between phototherapy (PT) and the development of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants.Study designA retrospective case-control study was conducted on VLBW infants with or without NEC (stage IIA or greater) born at & LE;35 weeks' gestation in a tertiary hospital over 7 years. Sample size calculation, trend test, as well as univariate and multiple logistic regression analyses were employed.ResultsA total of 824 VLBW infants were reviewed, with 74 cases and 122 controls finally enrolled. The odds of NEC increased with the duration and number of PT sessions. Exposure to >120 h and >4 instances of PT were significantly associated with NEC in multivariate analysis.ConclusionThis is the first study suggesting a potential association between PT and development of NEC in VLBW infants. This association needs further exploration."

基金机构：Scientific Research of Chongqing Health Center for Women and Children [2020YJQN01]; Scientific Research Cultivation Project of Chongqing Health Commission [2021FY109]; Joint Scientific Research Grants of Chongqing Health Commission and Science and Technology Bureau [2021MSXM116]

基金资助正文："This work was supported by Scientific Research of Chongqing Health Center for Women and Children (2020YJQN01), Scientific Research Cultivation Project of Chongqing Health Commission (2021FY109) and Joint Scientific Research Grants of Chongqing Health Commission and Science and Technology Bureau(2021MSXM116). The roles of the 2020YJQN01, 2021FY109 and 2021MSXM116 grants were to support the data collection, interpretation, and manuscript editing."