Association between transforming growth factors -beta and matrix metalloproteinases in the aqueous humor and plasma in myopic patients

作者全名："Yue, Y.; Che, D.; Hsiao, Y. W.; Zhou, J.; Zhao, K."

作者地址："[Yue, Y.; Che, D.; Hsiao, Y. W.; Zhou, J.] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, Sch Med, Shanghai 200011, Peoples R China; [Yue, Y.; Che, D.; Hsiao, Y. W.; Zhou, J.] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200011, Peoples R China; [Yue, Y.] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol,Dept Ophthalmol, Chongqing 400016, Peoples R China; [Zhao, K.] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Ophthalmol, Sch Med, 1678 Dongfang Rd, Shanghai 200127, Peoples R China"

通信作者："Zhao, K (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Ophthalmol, Sch Med, 1678 Dongfang Rd, Shanghai 200127, Peoples R China."

来源：JOURNAL FRANCAIS D OPHTALMOLOGIE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001043666400020

JCR分区：Q4

影响因子：1.2

年份：2022

卷号：45

期号：10

开始页：1177

结束页：1183

文献类型：Article

关键词：High myopia; TGF-beta; Matrix metalloproteinase; Aqueous humor; Plasma

摘要："Purpose. To investigate the relationship between levels of transforming growth factor beta TGF-13; (TGF-beta), matrix metalloproteinase (MMP) and tissue inhibitors of MMP (TIMP) in the aqueous Matrix humor (AH) and plasma (PL) of myopic patients. metalloproteinase Methods. Aqueous humor and plasma were collected intraoperatively from 37 myopic patients Aqueous humor; with various axial lengths (AL) during ICL surgery. The concentrations of TGF-131, TGF-132, Plasma TGF-1.13, MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 were measured using Luminex xMAP Technology kits (Milliplex xMAP kits). The association between TGF(3 and MMP/TIMP levels were analyzed based on the Spearman's correlation test or Pearson's correlation test. Results. There was a negative correlation between TGF-beta 1 and MMP-1, TIMP-2, TIMP-3 and TIMP-4 in the AH, and a positive correlation between TGF-beta 1 and MMP-1 in the PL. In the AH, levels of TGF-1.32 were positively correlated with levels of TIMP-3 (r = 0.441; P < 0.001). In the PL, levels of TGF-beta 2 also correlated positively with levels of TIMP-3 (r=0.427; P < 0.001)). Conclusion. The level of TGF-I32 was the highest among TGF-beta 3s in the AH. A consistent positive correlation between TGF-beta 2 and TIMP-3 was found both in the AH and PL, indicating that systemic levels of TGF-beta 2 and MMPs/TIMPs may also play a role in myopic progression. (c) 2022 Published by Elsevier Masson SAS."

基金机构：Science and Technology Commission of Shanghai [17DZ2260100]

基金资助正文：This work was supported by the Science and Technology Commission of Shanghai (17DZ2260100).