The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma

作者全名："Liu, Jiali; Xuan, Beibei; Quan, Quan; Gong, Sainan; Mu, Xiaoling"

作者地址："[Liu, Jiali; Xuan, Beibei; Quan, Quan; Gong, Sainan; Mu, Xiaoling] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, 1 Youyi Rd,, Chongqing 400016, Peoples R China"

通信作者："Mu, XL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, 1 Youyi Rd,, Chongqing 400016, Peoples R China."

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001043716800001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Endometrial carcinoma; Serum ferritin; Inflammation; Ferroptosis

摘要："BackgroundEndometrial carcinoma is a common malignant tumor in female reproductive system. At present, there is no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on the prognosis of endometrial carcinoma.MethodsData of 367 patients who diagnosed with endometrial carcinoma at the First Affiliated Hospital of Chongqing Medical University between January 2012 and August 2018 was retrospectively analyzed. The prediction accuracy was evaluated by receiver operating characteristics curves and Youden's J statistics. Hosmer-lemeshow test was used to confirm the goodness of fit of the model. The prognostic value of serum ferritin on disease free survival (DFS) and overall survival (OS) of endometrial carcinoma was evaluated by univariate log-rank tests and multivariate cox regression models.ResultsPreoperative high serum ferritin was correlated with older age, high grade, specific histological subtypes and recurrence of endometrial carcinoma (P < 0.05). The DFS and OS of 198 patients with elevated serum ferritin levels were significantly lower than those with low serum ferritin levels (P = 0.001 and P = 0.002, respectively). In multivariate analysis, serum ferritin was an independent prognostic factor for DFS and OS in endometrial carcinoma (P = 0.012, P = 0.028).ConclusionThrough our research, we found that the high expression of serum ferritin level was not only related to low DFS and OS in patients with endometrial carcinoma, but also related to the high-risk factors of endometrial carcinoma recurrence. So serum ferritin levels may be used to predict the poor prognosis of patients with endometrial carcinoma."

基金机构：Chongqing Science And Technology Bureau in China [cstc2017shmsA130034]

基金资助正文：This work was supported by Chongqing Science And Technology Bureau in China (cstc2017shmsA130034).