Pathogen diversity in meta-population networks

作者全名："Nie, Yanyi; Zhong, Xiaoni; Lin, Tao; Wang, Wei"

作者地址："[Nie, Yanyi; Zhong, Xiaoni; Wang, Wei] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Nie, Yanyi; Lin, Tao] Sichuan Univ, Coll Comp Sci, Chengdu 610065, Peoples R China"

通信作者："Wang, W (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China.; Lin, T (通讯作者)，Sichuan Univ, Coll Comp Sci, Chengdu 610065, Peoples R China."

来源：CHAOS SOLITONS & FRACTALS

ESI学科分类：PHYSICS

WOS号：WOS:001044404000001

JCR分区：Q1

影响因子：5.3

年份：2023

卷号：166

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Pathogen mutation; Pathogen diversity; Meta-population networks

摘要："The pathogen diversity means that multiple strains coexist, and widely exist in the biology systems. The new mutation of SARS-CoV-2 leading to worldwide pathogen diversity is a typical example. What are the main factors of inducing the pathogen diversity? Previous studies indicated the pathogen mutation is the most important reason for inducing the pathogen diversity. The traffic network and gene network are crucial in shaping the dynamics of pathogen contagion, while their roles for the pathogen diversity still lacking a theoretical study. To this end, we propose a reaction-diffusion process of pathogens with mutations on meta-population networks, which includes population movement and strain mutation. We extend the Microscopic Markov Chain Approach (MMCA) to describe the model. Traffic networks make pathogen diversity more likely to occur in cities with lower infection densities. The likelihood of pathogen diversity is low in cities with short effective distances in the traffic network. Star-type gene network is more likely to lead to pathogen diversity than lattice-type and chain-type gene networks. When pathogen localization is present, infection is localized to strains that are at the endpoints of the gene network. Both the increased probability of movement and mutation promote pathogen diversity. The results also show that the population tends to move to cities with short effective distances, resulting in the infection density is high."

基金机构："Social Science Foundation of Chongqing [2021PY53]; Natural Science Foundation of Chongqing, China [cstc2021jcyj-msxmX0132]; Natural Science Foundation of Yuzhong District, Chongqing [20210117]; National Natural Science Foundation of China [61903266]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202200429]"

基金资助正文："This work was partially supported by the Social Science Foundation of Chongqing, No. 2021PY53, Natural Science Foundation of Chongqing, China, No. cstc2021jcyj-msxmX0132, Natural Science Foundation of Yuzhong District, Chongqing, No. 20210117, National Natural Science Foundation of China under Grants No. 61903266, and Science and Technology Research Program of Chongqing Municipal Education Commission, No. KJQN202200429."