Visceral adipose tissue and risk of nonalcoholic fatty liver disease: A Mendelian randomization study

作者全名："Tao, Min; Zhou, Guanghong; Liu, Jing; He, Miao; Wang, Cong; Luo, Xie; Zhang, Lili"

作者地址："[Tao, Min; Zhou, Guanghong; Liu, Jing; He, Miao; Wang, Cong; Luo, Xie; Zhang, Lili] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Zhang, Lili] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China"

通信作者："Zhang, LL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China."

来源：CLINICAL ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001044820900001

JCR分区：Q2

影响因子：3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Mendelian randomization; nonalcoholic fatty liver disease; visceral adipose tissue

摘要："ObjectiveObservational studies have shown that visceral adipose tissue (VAT) can increase the risk of nonalcoholic fatty liver disease (NAFLD). However, the causality of this association remains unclear. Therefore, this study aimed to explore the causal association between VAT and NAFLD. DesignWe obtained single-nucleotide polymorphisms strongly associated with VAT (n = 325,153) from large-scale genome-wide association studies. Summary-level data for NAFLD (2275 cases and 375,002 controls) was available from the FinnGen consortium. We applied two-sample Mendelian randomization (MR) to determine the causal association between VAT and NAFLD. The random-effects inverse-variance weighted (IVW) method was used as the main MR approach, with alternate methods including the weighted median (WM) approach and MR-Egger regression. In addition, we conducted sensitivity analyses to assess the robustness of MR analyses. ResultsGenetically predicted higher VAT mass is causally associated with a higher risk of NAFLD. The three analysis results of MR were as follows: IVW (& beta; = 0.665, odds ratio [OR] = 1.944, 95% confidence interval [CI] = 1.482-2.550, p = 1.58e-06], WM (& beta; = 0.615, OR = 1.849, 95% CI = 1.272-2.689, p = 1.29e-03), and MR-Egger (& beta; = 1.250, OR = 3.490, 95% CI = 1.522-7.998, p = 3.52e-03). In the sensitivity analysis, the data showed heterogeneity (p < 0.05) but no pleiotropy (p = 0.145). ConclusionThis study provided genetic evidence that higher VAT mass causally associated with a higher risk of NAFLD. The amount of VAT could be reduced using a therapeutic strategy for managing NAFLD."

基金机构：UK Biobank; National Natural Science Foundation of China [81300702]; Natural Science Foundation Project of CSTC [cstc2018jcyjAXO210]

基金资助正文：We want to acknowledge the participants and investigators of the FinnGen study and UK Biobank. This research was supported by the National Natural Science Foundation of China (Grant No. 81300702 to L. Z.) and the Natural Science Foundation Project of CSTC (cstc2018jcyjAXO210 to L. Z).