Programmed cell death of periodontal ligament cells

作者全名："He, Wei; Fu, Yu; Yao, Song; Huang, Lan"

作者地址："[He, Wei; Fu, Yu; Yao, Song; Huang, Lan] Chongqing Med Univ, Coll Stomatol, Dept Orthodont, Chongqing, Peoples R China; [He, Wei; Fu, Yu; Yao, Song; Huang, Lan] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [He, Wei; Fu, Yu; Yao, Song; Huang, Lan] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Huang, Lan] Chongqing Med Univ, 426,North Songshi Rd,Yubei Dist, Chongqing 401147, Peoples R China"

通信作者："Huang, L (通讯作者)，Chongqing Med Univ, 426,North Songshi Rd,Yubei Dist, Chongqing 401147, Peoples R China."

来源：JOURNAL OF CELLULAR PHYSIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001045476500001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：apoptosis; autophagy; cementoblasts; diabetes; hypoxia; periodontal ligament fibroblasts

摘要："The periodontal ligament is a crucial tissue that provides support to the periodontium. Situated between the alveolar bone and the tooth root, it consists primarily of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. Fibroblasts, cementoblasts, osteoblasts, and osteoclasts are functionally differentiated cells, whereas PDLSCs are undifferentiated mesenchymal stem cells. The dynamic development of these cells is intricately linked to periodontal changes and homeostasis. Notably, the regulation of programmed cell death facilitates the clearance of necrotic tissue and plays a pivotal role in immune response. However, it also potentially contributes to the loss of periodontal supporting tissues and root resorption. These findings have significant implications for understanding the occurrence and progression of periodontitis, as well as the mechanisms underlying orthodontic root resorption. Further, the regulation of periodontal ligament cell (PDLC) death is influenced by both systemic and local factors. This comprehensive review focuses on recent studies reporting the mechanisms of PDLC death and related factors."

基金机构：National Natural Science Foundation of China [82170989]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0794]

基金资助正文：ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (82170989) and the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0794). Image was created by Figdraw.