The role of anti-HMGB1 antibody and anti-moesin antibody in ANCA-associated vasculitis

作者全名："Wang, Yanping; Shi, Jing; Tan, Caiping; Zou, Lin; Chen, Pu; Luo, Peng"

作者地址："[Wang, Yanping; Shi, Jing; Tan, Caiping; Zou, Lin; Chen, Pu; Luo, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China"

通信作者："Wang, YP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China."

来源：MEDICINA CLINICA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001047446900001

JCR分区：Q1

影响因子：2.6

年份：2023

卷号：161

期号：3

开始页：101

结束页：106

文献类型：Article

关键词：ANCA-associated vasculitis; Anti-HMGB1 antibody; Anti-moesin antibody; Diagnosis; Clinical features

摘要："Objective: The study aims to evaluate the role of anti-high mobility group box 1 (HMGB1) antibody and anti-moesin antibody in the diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and its possible relationship with the different clinical manifestations.Methods: The study involved 60 AAV patients, 58 patients with autoimmune disease other than AAV and 50 healthy subjects. The serum levels of anti-HMGB1 and anti-moesin antibodies were determined by enzyme-linked immunosorbent assay (ELISA), and the second determination was made 3 months after treatment of AAV patients.Results: Serum levels of anti-HMGB1 and anti-moesin antibodies in AAV group were significantly higher than those in non-AAV group and HC group. The area under the curve (AUC) of anti-HMGB1 and anti-moesin in diagnosing AAV were 0.977 and 0.670, respectively. Anti-HMGB1 levels were significantly elevated in AAV patients with pulmonary involvement, while the concentrations of anti-moesin were significantly increased in patients with renal damage. Anti-moesin were positively correlated with BVAS (r = 0.261, P = 0.044), creatinine (r = 0.296, P = 0.024) and negatively correlated with complement C3 (r = -0.363, P = 0.013). Besides, anti-moesin levels of active AAV patients were significantly higher than those in inactive patients. The concentrations of serum anti-HMGB1 could be significantly decreased after induction remission treatment (P < 0.05).Conclusion: Anti-HMGB1 and anti-moesin antibodies play important roles in the diagnosis and prognosis of AAV, which may act as potential disease markers for AAV.& COPY; 2023 Elsevier Espan & SIM;a, S.L.U. All rights reserved."

基金机构：Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0349]

基金资助正文："Funding This study was supported by Natural Science Foundation of Chongqing (grant numbers cstc2019jcyj-msxmX0349) , China."