MPFC PV plus interneurons are involved in the antidepressant effects of running exercise but not fluoxetine therapy

作者全名："Qin, Lu; Liang, Xin; Qi, Yingqiang; Luo, Yanmin; Xiao, Qian; Huang, Dujuan; Zhou, Chunni; Jiang, Lin; Zhou, Mei; Zhou, Yuning; Tang, Jing; Tang, Yong"

作者地址："[Qin, Lu; Huang, Dujuan; Zhou, Chunni; Zhou, Mei; Zhou, Yuning; Tang, Jing; Tang, Yong] Chongqing Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Chongqing 400016, Peoples R China; [Qin, Lu; Liang, Xin; Luo, Yanmin; Xiao, Qian; Huang, Dujuan; Zhou, Chunni; Jiang, Lin; Zhou, Mei; Zhou, Yuning; Tang, Jing; Tang, Yong] Chongqing Med Univ, Sch Basic Med Sci, Lab Stem Cells & Tissue Engn, Chongqing 400016, Peoples R China; [Liang, Xin] Chongqing Med Univ, Sch Basic Med Sci, Dept Pathol, Chongqing 400016, Peoples R China; [Qi, Yingqiang] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Luo, Yanmin] Chongqing Med Univ, Sch Basic Med Sci, Dept Physiol, Chongqing 400016, Peoples R China; [Xiao, Qian] Chongqing Med Univ, Sch Basic Med Sci, Dept Radioact Med, Chongqing 400016, Peoples R China; [Jiang, Lin] Chongqing Med Univ, Lab Teaching & Management Ctr, Chongqing 400016, Peoples R China"

通信作者："Tang, J; Tang, Y (通讯作者)，Chongqing Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Chongqing 400016, Peoples R China."

来源：NEUROPHARMACOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001047706100001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：238

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Depression; Exercise; MPFC; Stereology; Dendrite; PV plus interneurons

摘要："Depression is a complex psychiatric disorder. Previous studies have shown that running exercise reverses depression-like behavior faster and more effectively than fluoxetine therapy. GABAergic interneurons, including the PV+ interneuron subtype, in the medial prefrontal cortex (MPFC) are involved in pathological changes of depression. It was unknown whether running exercise and fluoxetine therapy reverse depression-like behavior via GABAergic interneurons or the PV+ interneurons subtype in MPFC. To address this issue, we subjected mice with chronic unpredictable stress (CUS) to a 4-week running exercise or fluoxetine therapy. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that running exercise enriched GABAergic synaptic pathways in the MPFC of CUS-exposed mice. However, the number of PV+ interneurons but not the total number of GABAergic interneurons in the MPFC of CUS-exposed mice reversed by running exercise, not fluoxetine therapy. Running exercise increased the relative gene expression levels of the PV gene in the MPFC of CUSexposed mice without altering other subtypes of GABAergic interneurons. Moreover, running exercise and fluoxetine therapy both significantly improved the length, area and volume of dendrites and the spine morphology of PV+ interneurons in the MPFC of mice exposed to CUS. However, running exercise but not fluoxetine therapy improved the dendritic complexity level of PV+ interneurons in the MPFC of CUS-exposed mice. In summary, the number and dendritic complexity level of PV+ interneurons may be important therapeutic targets for the mechanism by which running exercise reverses depression-like behavior faster and more effectively than fluoxetine therapy."

基金机构："National Natural Science Foundation of China (NSFC) [82171522, 81871073]"

基金资助正文："National Natural Science Foundation of China (NSFC, 82171522 and 81871073) provided funding for this work."