A Metal-Free strategy for the synthesis of tetrasubstituted Pyridines: Dimethyl sulfoxide as carbon source

作者全名："Zhang, Xiu Yu; Liu, Kai; Li, Suzhen; Li, Yanwu; Wu, Yue; Li, Xiang; Ran, Xiaoting; Liu, Aqin; Yuan, Jianyong"

作者地址："[Li, Suzhen; Li, Yanwu; Wu, Yue; Li, Xiang; Ran, Xiaoting; Liu, Aqin; Yuan, Jianyong] Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China; [Zhang, Xiu Yu] Peoples Hosp Kaizhou Dist, Dept Pharm, Chongqing, Peoples R China; [Liu, Kai] Chongqing Publ Hlth Med Ctr, Dept Pharm, Chongqing, Peoples R China"

通信作者："Yuan, JY (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Med Chem, Chongqing 400016, Peoples R China."

来源：TETRAHEDRON LETTERS

ESI学科分类：CHEMISTRY

WOS号：WOS:001048118400001

JCR分区：Q3

影响因子：1.5

年份：2023

卷号：126

期号：　

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结束页：　

文献类型：Article

关键词：Enaminone; Imidazolium chloride; Pyridine; DMSO; Contents

摘要："An efficient and practical approach for the synthesis of tetrasubstituted pyridines has been described via the Imidazole hydrochloride-promoted reaction of enaminones with DMSO. This protocol showed good functional group tolerance, and a series of pyridines were synthesized in moderate to good yields without metal catalysts. A multi-gram scale reaction was also performed to ensure the scalability of the reaction. Notably, DMSO plays two vital roles: carbon source and solvent. & COPY; 2023 Elsevier Ltd. All rights reserved."

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