"Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies"

作者全名："Cheng, Fang; Zhang, Ruoqi; Sun, Chen; Ran, Qian; Zhang, Cuihan; Shen, Changhong; Yao, Ziqing; Wang, Miao; Song, Lin; Peng, Cheng"

作者地址："[Cheng, Fang; Zhang, Ruoqi; Sun, Chen; Ran, Qian; Zhang, Cuihan; Shen, Changhong; Yao, Ziqing; Wang, Miao; Peng, Cheng] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China; [Song, Lin] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,Dept Pha, Chongqing, Peoples R China"

通信作者："Peng, C (通讯作者)，Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.; Song, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,Dept Pha, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001048564900001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：oxaliplatin; peripheral neurotoxicity; colorectal cancer; adverse reaction; mechanism; pharmacokinetics; therapeutic strategies

摘要："Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer (CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose-limiting clinical problem that might lead to treatment interruption. This neuropathy may be reversible after treatment discontinuation. Its complicated mechanisms are related to DNA damage, dysfunction of voltage-gated ion channels, neuroinflammation, transporters, oxidative stress, and mitochondrial dysfunction, etc. Several strategies have been proposed to diminish OIPN without compromising the efficacy of adjuvant therapy, namely, combination with chemoprotectants (such as glutathione, Ca/Mg, ibudilast, duloxetine, etc.), chronomodulated infusion, dose reduction, reintroduction of oxaliplatin and topical administration [hepatic arterial infusion chemotherapy (HAIC), pressurized intraperitoneal aerosol chemotherapy (PIPAC), and hyperthermic intraperitoneal chemotherapy (HIPEC)]. This article provides recent updates related to the potential mechanisms, therapeutic strategies in treatment of OIPN, and pharmacokinetics of several methods of oxaliplatin administration in clinical trials."

基金机构：Natural Science Foundation of Sichuan Province [2022NSFSC1349]; Xinglin Scholar Fund of CDUTCM [QJRC2022023]

基金资助正文：Funding This work was supported by the Natural Science Foundation of Sichuan Province (2022NSFSC1349) and Xinglin Scholar Fund of CDUTCM (QJRC2022023).