A meta-analysis of the Zilongjin tablets for non-small cell lung cancer and its network pharmacology of action against NSCLC and COVID-19

作者全名："Yang, Wuxia; Zhang, Yichao; Gao, Jing; Hu, Pengcheng; Yang, Yanjie; Xu, Xiaoqing"

作者地址："[Yang, Wuxia; Xu, Xiaoqing] Tianjin Med Univ, Grad Sch, Tianjin, Peoples R China; [Zhang, Yichao] Qinghai Univ, Grad Sch, Xining, Peoples R China; [Gao, Jing] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Clin Lab, Tianjin, Peoples R China; [Gao, Jing] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin, Peoples R China; [Hu, Pengcheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Chongqing, Peoples R China; [Yang, Yanjie] Southern Med Univ, Shunde Hosp, Foshan, Peoples R China"

通信作者："Xu, XQ (通讯作者)，Tianjin Med Univ, Grad Sch, Tianjin, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001049107500001

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Zilongjin tablets; non-small cell lung cancer (NSCLC); COVID-19; traditional Chinese medicine; meta-analysis; network pharmacology

摘要："Objective: To objectively evaluate the efficacy of the Zilongjin tablets in non-small cell lung cancer (NSCLC) and to explore its potential mechanism of action against NSCLC and COVID-19 based on network pharmacology.Methods: The database was searched for randomized controlled trials (RCTs) of the Zilongjin tablets for NSCLC published up to 22 August 2022. The quality of included trials was assessed using Cochrane standard guidelines, and a meta-analysis was performed using Rev Man 5.3. Gene targets for intersections of NSCLC and COVID-19 (the NC) and drugs were obtained from the TCMSP database, HERB database, GeneCards database, and the NCBI database for network pharmacology research.Results: Meta-analysis included 14 articles with 2,430 patients. The meta-analysis showed that the Zilongjin tablets combined with conventional chemotherapy were significantly more effective than chemotherapy alone in the treatment of NSCLC. A total of 29 drug-disease intersecting targets were identified in the network pharmacology. The ""ingredient-target-pathway"" diagram component-target-pathway network contained 119 nodes and 429 edges, with the majority of targets associated with inflammatory responses.Conclusion: The efficacy and quality of life of the Zilongjin tablets combined conventional chemotherapy for NSCLC were significantly better than chemotherapy alone, alleviating various adverse effects. At the same time, the Zilongjin tablets may modulate the inflammatory response to alleviate NSCLC and COVID-19."

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