Research Progress of Interleukin-27 in Inflammatory Bowel Disease

作者全名："Wang, Qing; Chen, Feifan; Peng, Yingqiu; Yi, Xuanyu; He, Yu; Shi, Yuan"

作者地址："[Wang, Qing; Chen, Feifan; Peng, Yingqiu; Yi, Xuanyu; He, Yu; Shi, Yuan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China; [He, Yu] Chongqing Med Univ, Childrens Hosp, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China"

通信作者："He, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, 136 Zhongshan 2nd Rd, Chongqing, Peoples R China."

来源：INFLAMMATORY BOWEL DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001049264500001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：interleukin-27; inflammatory bowel disease

摘要："Inflammatory bowel disease (IBD) can be identified as an inflammatory disorder in the intestine, being characterized by maladjusted immune responses and chronic inflammation of the intestinal tract. However, as the etiology and pathogenesis are still unclear, more effective therapeutic approaches are needed. Recent studies have discovered a new cytokine, interleukin-27 (IL-27), which belongs to the superfamily of IL-6 and IL-12, demonstrating multiple functions in many infectious diseases, autoimmune diseases, and cancers. Interleukin-27 is mainly produced by antigen presentation cells (APCs) such as dendritic cells and mononuclear macrophages, playing a dual regulatory role in immunological response. Therefore, this updated review aims to summarize the new progress of the regulatory role of IL-27 in IBD and focus more on the interaction between IL-27 and immune cells, hoping to provide more evidence for the potential IBD treatment mediated by IL-27. This review aims to summarize the new progress of the regulatory role of IL-27 in IBD and focus more on the interaction between IL-27 and immune cells, hoping to provide more evidence for the potential IBD treatment mediated by IL-27."

基金机构：National Key Research and Development Program of China [2022YFC2704802]; National Natural Science Foundation of China [82001602]

基金资助正文：Supported by the National Key Research and Development Program of China (No. 2022YFC2704802) and the National Natural Science Foundation of China (No. 82001602)