The aortic calcification is a risk factor for colorectal anastomotic leakage

作者全名："Liu, Xu-Rui; Liu, Fei; Zhang, Wei; Peng, Dong"

作者地址："[Liu, Xu-Rui; Liu, Fei; Zhang, Wei; Peng, Dong] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Peng, D (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：UPDATES IN SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001049988900001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Article; Early Access

关键词：Aortic calcification; Anastomotic leakage; Colorectal cancer; Surgical outcomes

摘要："PurposeThe current pooling up analysis aimed to evaluate whether aortic calcification (AC) was a potential risk factor for anastomotic leakage (AL) after colorectal surgery.MethodsIn this study, we searched studies in three databases including PubMed, Embase, and the Cochrane Library on April 20, 2022. In order to investigate the association between AC and AL, the hazard ratios (HRs) and 95% confidence intervals (CIs) of AC were pooled up. Our study was performed with RevMan 5.3 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsWe finally enrolled eight studies involving 1955 patients for statistical analysis. As for all patients, we found that AC could significantly increase the risk of AL after surgery (HR = 2.31, I-2 = 0%, 95%CI = 1.58 to 3.38, P < 0.01). In five studies including patients undergoing colorectal surgery (benign diseases and cancers), AC was also a risk factor for AL (HR = 3.30, I-2 = 2%; 95%CI = 1.83 to 5.95, P < 0.01). In terms of the other three studies that only included CRC patients, there was still a correction between AC and AL (HR = 1.80, I-2 = 0%, 95%CI = 1.10 to 2.96, P = 0.02).ConclusionPatients with AC were more likely to develop AL after colorectal surgery. Moreover, subgroup analysis suggested that AC was a predictor for AL after CRC surgery."

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