A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19

作者全名："Kao, Guoying; Chen, Yunlin; Xiao, Jun; Fan, Jinqi"

作者地址："[Kao, Guoying; Xiao, Jun] Chongqing Univ, Chongqing Emergency Med Ctr, Dept Cardiovasc Med, Cent Hosp, Chongqing, Peoples R China; [Chen, Yunlin; Fan, Jinqi] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China; [Fan, Jinqi] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Cardiac Arrhythmias Serv Ctr, Dept Cardiol, Chongqing 400010, Peoples R China"

通信作者："Fan, JQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Cardiac Arrhythmias Serv Ctr, Dept Cardiol, Chongqing 400010, Peoples R China."

来源：INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001050075000001

JCR分区：Q4

影响因子：0.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：statin; COVID-19; meta-analysis; outcome; ran-domized controlled trials

摘要："Background: Previous observational studies and meta-analyses have suggested that statins could be beneficial in reducing the risk of adverse clinical outcomes. This study is the first to conduct a meta analysis of recently published randomized controlled clinical trials investigating the potential therapeutic benefits of statins for COVID-19. Materials and methods: A thorough search was conducted using databases such as PubMed and Embase until May 2023 to identify randomized controlled clinical trials investigating the use of statins in patients with COVID-19. Review Manager 5.4 was used to analyze the selected studies. Results: Seven randomized controlled trials comprising a total of 2,370 patients were included in this study. Of these, 1,295 patients received statin therapy, while 1,075 received placebo or other drugs. All included studies were conducted on inpatients with an average age of 45 - 61 years, and the proportion of patients with diabetes and coronary heart disease was less than 30%. One study only included severely ill patients. Our results showed that statin treatment did not significantly reduce hospitalized patient mortality (11.5 vs. 13.4%, p = 0.94), the proportion of patients transferred to intensive care due to disease changes (14.2 vs. 11.2%, p = 0.41), or the proportion of patients requiring mechanical ventilation (5.3 vs. 7.9%, p = 0.71) compared to controls. However, the use of statins was associated with a slight increase in hospital stay. Conclusion: A critical appraisal of published randomized controlled trials on statin therapy in COVID-19 did not show any significant effect on mortality, the risk of transfer to intensive care, or mechanical ventilation."

基金机构：Gen-eral Program of Health and Family Plan-ning Commission of Chongqing [2015MSXM020]; Program for Innovative Research Team of Chongqing Kuanren Hospital

基金资助正文："Funding This study was supported by the Gen-eral Program of Health and Family Plan-ning Commission of Chongqing (Grant No. 2015MSXM020, Fan JQ) , and the Program for Innovative Research Team of Chongqing Kuanren Hospital."