Effect of statin treatment on clinical outcomes in cardioembolic stroke with endovascular thrombectomy

作者全名："Gong, Chen; Liu, Chang; Wang, You; Chen, Liyuan; Yuan, Jinxian; Zhang, Jie; Li, Xiaoming; Chen, Yanru; Huang, Liping; Xu, Tao; Chen, Yangmei"

作者地址："[Gong, Chen; Liu, Chang; Wang, You; Chen, Liyuan; Yuan, Jinxian; Zhang, Jie; Chen, Yanru; Huang, Liping; Xu, Tao; Chen, Yangmei] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China; [Li, Xiaoming] Chongqing Univ, Dept Intens Care Unit, Canc Hosp, Chongqing, Peoples R China; [Xu, Tao; Chen, Yangmei] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Xu, T; Chen, YM (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：JOURNAL OF NEUROINTERVENTIONAL SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001050209100001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Thrombectomy; Stroke; Drug

摘要："BackgroundWhile statins have been widely used in patients with large-artery atherosclerotic stroke, their effectiveness in patients with cardioembolic large vessel occlusion (CE-LVO) undergoing endovascular treatment (EVT) remains unclear. This study aimed to evaluate whether combining statin therapy with EVT could improve clinical outcomes in patients with acute ischemic stroke caused by CE-LVO in the anterior circulation. MethodsWe performed a retrospective screening on patients with CE-LVO in the anterior circulation who underwent EVT in 27 hospitals across China between 2018 and 2021. The primary outcome measure was functional independence, defined as a 90-day modified Rankin Scale (mRS) score of 0 to 2. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH). ResultsA total of 510 patients with CE-LVO in the anterior circulation undergoing EVT were included in this study. Of these, 404 (79.2%) patients received statin treatment (statin group), while 106 (20.8%) did not (non-statin group). Statin treatment was significantly associated with improved functional independence (adjusted OR (aOR) 2.072, 95% CI 1.197 to 3.586, P=0.009). Moreover, statin use was associated with a lower rate of 90-day mortality (aOR 0.343, 95% CI 0.197 to 0.596, P<0.001) and a lower rate of sICH (aOR 0.153, 95% CI 0.072 to 0.325, P<0.001). ConclusionStatin treatment was associated with improved clinical outcomes and reduced risks of mortality and sICH in patients with CE-LVO in the anterior circulation undergoing EVT."

基金机构：National Natural Science Foundation of China [82001264]; Chongqing Technology Innovation and Application Development [2022TIAD-KPX0017]

基金资助正文："This work was supported by National Natural Science Foundation of China (No. 82001264), Chongqing Technology Innovation and Application Development & nbsp;(No. 2022TIAD-KPX0017)."