Antihypertensive drugs may not delay the symptom progression of Parkinson's disease: A 2-year follow-up study

作者全名："Dong, Zhaoying; Zuo, Rui; Zhong, Xiaoni; Zhang, Changhong; Zou, Xiaoya; Tian, Yuan; Zuo, Hongzhou; Du, Xinyi; Yu, Qian; Cheng, Oumei"

作者地址："[Dong, Zhaoying; Zou, Xiaoya; Tian, Yuan; Zuo, Hongzhou; Du, Xinyi; Yu, Qian; Cheng, Oumei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Zuo, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing 400016, Peoples R China; [Zhong, Xiaoni] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China; [Zhang, Changhong] Chengdu Ctr Dis Control & Prevent, Chengdu 610041, Sichuan, Peoples R China; [Cheng, Oumei] Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400000, Peoples R China"

通信作者："Cheng, OM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400000, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001050342100001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：Parkinson 's disease; Antihypertensive drug; Motor symptoms; Dopamine transporter

摘要："Background: Parkinson's disease (PD) is one of the most common neurodegenerative disease, and half of PD patients have hypertension as well. The effect of antihypertensive drugs on the pro-gression of PD has been less studied. The focus of this study was on the changes in dopamine transporter (DAT) levels to assess the effect of antihypertensive drugs on the progression of PD. Methods: Data from 321 drug-naive patients from the Parkinson's Disease Progression Marker Initiative (PPMI) were collected over a 2-year period. Patients were divided into the PD with arterial hypertension (AH) group (102 cases) with antihypertensive drugs, the PD with other cardiovascular risk factors (CVRFs) group (60 cases) with antidiabetic and/or lipid-lowering drugs, and the pure PD group (159 cases) without CVRFs. The Movement Disorder Society Sponsored Revision Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Hoehn-Yahr (H & Y) stage were used to assess progression. DAT semiquantitative values were used to eval-uate damage to dopaminergic neurons in the substantia nigra, including the contralateral and ipsilateral count density ratio and asymmetry index.Results: There were no significant differences among the three groups in MDS-UPDRS score and H & Y stage. Changes in DAT levels among the three groups were without distinct differences in the first year and second year. In each group, DAT decreased more in the first year than in the second year. There was no decrease in DAT uptake in the PD with AH group compared with the other groups during the follow-up period.Conclusions: There is no evidence that antihypertensive drugs can delay PD progression within 2 years."

基金机构：National Natural Science Foundation of China [81871002]; Joint Project of Chongqing Health Commission and Science and Technology Bureau [2022MSXM182]

基金资助正文：Funding This research was supported by the National Natural Science Foundation of China (No. 81871002) and the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2022MSXM182) . All participation centers were approved by respective institutional review boards. Informed consent forms were signed by all patients. (All the data were obtained from the PPMI database.) The statement that all authors have approved the final article is true and included in the disclosure.