Sex difference in cerebral atherosclerotic stenosis in Chinese asymptomatic subjects

作者全名："Tao, Xiangkun; Qiao, Renjie; Liu, Can; Guo, Lu; Li, Jingcheng; Kang, Yulai; Wei, Youdong"

作者地址："[Tao, Xiangkun] Chongqing Med Univ, Psychol Med Sci, Chongqing, Peoples R China; [Qiao, Renjie] Chongqing Med Univ, Clin Med Sci, Chongqing, Peoples R China; [Liu, Can] Army Med Univ, Daping Hosp, Dept Radiol, Chongqing 400042, Peoples R China; [Guo, Lu; Li, Jingcheng; Kang, Yulai] Army Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China; [Wei, Youdong] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Wei, Youdong] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [Wei, Youdong] 1 Youyi Rd, Chongqing, Peoples R China; [Kang, Yulai] 10 Changjiang Branch Rd, Chongqing, Peoples R China"

通信作者："Wei, YD (通讯作者)，1 Youyi Rd, Chongqing, Peoples R China.; Kang, YL (通讯作者)，10 Changjiang Branch Rd, Chongqing, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001050354900001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：Sex difference; Atherosclerosis; Stenosis; Cerebral artery; Vascular risk factor

摘要："Background and purpose: Sex difference in cerebral atherosclerosis has been noted in previous studies, but the precise characteristics remain incompletely elucidated. This study aims to identify the sex difference in patients with asymptomatic cerebrovascular stenosis. Materials and methods: The image and clinical data of 1305 consecutive patients who had head and neck computed tomography angiography (CTA) were collected. Fifty hundred and seventy-three patients (287 males) with asymptomatic atherosclerotic stenosis in cerebral arteries were finally included. The stenosis number, distribution, severity and their changes with age were analyzed and compared between males and females. Simple linear regression was used to assess the change in lesions with age. Results: A total of 2097 stenoses were identified in 573 patients, males had more stenoses than females (3 [2, 5] vs 3 [2, 4], p=0.015). The number of stenoses in extracranial arteries was much higher in males (p = 0.001). Females had higher percentage of stenosis in anterior (89.6% vs 85.9%, p = 0.012) and intracranial arteries (63.3% vs 57.1%, p = 0.004) than males. Males had higher percentage of moderate-severe stenosis (5.1% vs 3.2%, p = 0.026). Age (OR = 1.67; 95% CI 1.24-2.25; p < 0.001) and hypertension (OR = 2.53; 95% CI 1.24-5.15; p = 0.01) were associated with moderate-severe stenosis. In patients over 50 years old, the number of stenoses increased by 1.03 per 10 years (p < 0.001), with 0.72 more stenoses in males (p = 0.003). Conclusions: Cerebral atherosclerotic stenosis was different between sexes regarding the distri-bution, severity and the change pattern with age, which underline the sex specific management in patients with cerebral atherosclerosis."

基金机构："National Natural Science Foundation of China [NSFC 81771287]; Chongqing Health and Family Planning Commission [2017MSXM023, 2017ZBXM046]"

基金资助正文：Financial Support This study was supported by National Natural Science Foundation of China (NSFC 81771287) and Chongqing Health and Family Planning Commission under grant numbers (2017MSXM023 and 2017ZBXM046) .